Gurushankar Chandramouly
Overview
Explore the profile of Gurushankar Chandramouly including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
768
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Recent Articles
1.
Le B, Vekariya U, Toma M, Nieborowska-Skorska M, Caron M, Gozdecka M, et al.
bioRxiv
. 2024 Oct;
PMID: 39411165
Myeloid malignancies carrying somatic DNMT3A mutations (DNMT3Amut) are usually resistant to standard therapy. DNMT3Amut leukemia cells accumulate toxic DNA double strand breaks (DSBs) and collapsed replication forks, rendering them dependent...
2.
Ito F, Li Z, Minakhin L, Chandramouly G, Tyagi M, Betsch R, et al.
Nat Commun
. 2024 Aug;
15(1):7003.
PMID: 39143110
DNA polymerase theta (Polθ) is a DNA helicase-polymerase protein that facilitates DNA repair and is synthetic lethal with homology-directed repair (HDR) factors. Thus, Polθ is a promising precision oncology drug-target...
3.
Vekariya U, Minakhin L, Chandramouly G, Tyagi M, Kent T, Sullivan-Reed K, et al.
Nat Commun
. 2024 Jul;
15(1):5822.
PMID: 38987289
DNA polymerase theta (Polθ)-mediated end-joining (TMEJ) repairs DNA double-strand breaks and confers resistance to genotoxic agents. How Polθ is regulated at the molecular level to exert TMEJ remains poorly characterized....
4.
Fried W, Tyagi M, Minakhin L, Chandramouly G, Tredinnick T, Ramanjulu M, et al.
Nat Commun
. 2024 Apr;
15(1):2862.
PMID: 38580648
The DNA damage response (DDR) protein DNA Polymerase θ (Polθ) is synthetic lethal with homologous recombination (HR) factors and is therefore a promising drug target in BRCA1/2 mutant cancers. We...
5.
Calbert M, Chandramouly G, Adams C, Saez-Ayala M, Kent T, Tyagi M, et al.
Mol Cancer Ther
. 2023 Dec;
23(5):683-699.
PMID: 38064712
Anticancer nucleosides are effective against solid tumors and hematologic malignancies, but typically are prone to nucleoside metabolism resistance mechanisms. Using a nucleoside-specific multiplexed high-throughput screening approach, we discovered 4'-ethynyl-2'-deoxycytidine (EdC)...
6.
Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert M, Tredinnick T, et al.
Nat Struct Mol Biol
. 2023 Apr;
30(7):1048.
PMID: 37059901
No abstract available.
7.
Vekariya U, Toma M, Nieborowska-Skorska M, Le B, Caron M, Kukuyan A, et al.
Blood
. 2022 Dec;
141(19):2372-2389.
PMID: 36580665
Leukemia cells accumulate DNA damage, but altered DNA repair mechanisms protect them from apoptosis. We showed here that formaldehyde generated by serine/1-carbon cycle metabolism contributed to the accumulation of toxic...
8.
Chandramouly G, Jamsen J, Borisonnik N, Tyagi M, Calbert M, Tredinnick T, et al.
Nat Struct Mol Biol
. 2022 Dec;
30(1):107-114.
PMID: 36536104
The double-strand break (DSB) repair pathway called microhomology-mediated end-joining (MMEJ) is thought to be dependent on DNA polymerase theta (Polθ) and occur independently of nonhomologous end-joining (NHEJ) factors. An unresolved...
9.
Chandramouly G
Adv Exp Med Biol
. 2022 May;
1360:55-67.
PMID: 35505162
Growth arrest and DNA damage 45 (Gadd45) family genes, Gadd45A, Gadd45B, and GADD45 G are implicated as stress sensors that are rapidly induced upon genotoxic/physiological stress. They are involved in...
10.
Chandramouly G, Zhao J, McDevitt S, Rusanov T, Hoang T, Borisonnik N, et al.
Sci Adv
. 2021 Jun;
7(24).
PMID: 34117057
Genome-embedded ribonucleotides arrest replicative DNA polymerases (Pols) and cause DNA breaks. Whether mammalian DNA repair Pols efficiently use template ribonucleotides and promote RNA-templated DNA repair synthesis remains unknown. We find...