Rajula Elango
Overview
Explore the profile of Rajula Elango including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
1031
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0
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Recent Articles
1.
Elango R, Nilavar N, Li A, Nguyen D, Rass E, Duffey E, et al.
Mol Cell
. 2024 Dec;
85(1):78-90.e3.
PMID: 39631396
Replication fork collision with a DNA nick can generate a one-ended break, fostering genomic instability. The opposing fork's collision with the nick could form a second DNA end, enabling conservative...
2.
Elango R, Nilavar N, Li A, Duffey E, Jiang Y, Nguyen D, et al.
bioRxiv
. 2024 Apr;
PMID: 38645103
Collision of a replication fork with a DNA nick is thought to generate a one-ended break, fostering genomic instability. Collision of the opposing converging fork with the nick could, in...
3.
Elango R, Panday A, Willis N, Scully R
STAR Protoc
. 2022 Aug;
3(3):101551.
PMID: 36042887
In this protocol, we use CRISPR/Cas9 to generate large deletions of the entire coding region of a gene of interest, generating a hemizygous cell line. Next, we systematically engineer precise...
4.
Elango R, Panday A, Lach F, Willis N, Nicholson K, Duffey E, et al.
Nat Struct Mol Biol
. 2022 Aug;
29(8):801-812.
PMID: 35941380
Vertebrate replication forks arrested at interstrand DNA cross-links (ICLs) engage the Fanconi anemia pathway to incise arrested forks, 'unhooking' the ICL and forming a double strand break (DSB) that is...
5.
Panday A, Elango R, Willis N, Scully R
STAR Protoc
. 2022 Aug;
3(3):101529.
PMID: 35928003
Chromatin immunoprecipitation coupled with quantitative PCR (ChIP-qPCR) even with optimization may give low signal-to-background ratio and spatial resolution. Here, we adapted Cleavage Under Targets and Release Using Nuclease (CUT&RUN) (originally...
6.
Scully R, Elango R, Panday A, Willis N
Curr Opin Genet Dev
. 2021 Aug;
71:154-162.
PMID: 34464818
Replication fork stalling occurs when the replisome encounters a barrier to normal fork progression. Replisome stalling events are common during scheduled DNA synthesis, but vary in their severity. At one...
7.
Panday A, Willis N, Elango R, Menghi F, Duffey E, Liu E, et al.
Mol Cell
. 2021 Apr;
81(11):2428-2444.e6.
PMID: 33882298
Repair pathway "choice" at stalled mammalian replication forks is an important determinant of genome stability; however, the underlying mechanisms are poorly understood. FANCM encodes a multi-domain scaffolding and motor protein...
8.
Liu L, Yan Z, Osia B, Twarowski J, Sun L, Kramara J, et al.
Nature
. 2021 Jan;
590(7847):655-659.
PMID: 33473214
Break-induced replication (BIR) repairs one-ended double-strand breaks in DNA similar to those formed by replication collapse or telomere erosion, and it has been implicated in the initiation of genome instability...
9.
Osia B, Elango R, Kramara J, Roberts S, Malkova A
Methods Mol Biol
. 2020 Aug;
2153:307-328.
PMID: 32840789
Repair of double-strand DNA breaks (DSBs) is important for preserving genomic integrity and stability. Break-induced replication (BIR) is a mechanism aimed to repair one-ended double-strand DNA breaks, similar to those...
10.
Elango R, Osia B, Harcy V, Malc E, Mieczkowski P, Roberts S, et al.
Nucleic Acids Res
. 2019 Aug;
47(18):9666-9684.
PMID: 31392335
Break induced replication (BIR) is a double strand break repair pathway that can promote genetic instabilities similar to those observed in cancer. Instead of a replication fork, BIR is driven...