Nicholas A Willis
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Explore the profile of Nicholas A Willis including associated specialties, affiliations and a list of published articles.
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27
Citations
2356
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Recent Articles
1.
Kozlova N, Cruz K, Doh H, Ruzette A, Willis N, Hong S, et al.
bioRxiv
. 2025 Feb;
PMID: 39896456
Summary Paragraph: Drug resistance is a severe clinical problem in stroma-rich tumours, such as pancreatic ductal adenocarcinoma (PDAC), and patients often relapse within a few months on chemotherapy . The...
2.
Elango R, Nilavar N, Li A, Nguyen D, Rass E, Duffey E, et al.
Mol Cell
. 2024 Dec;
85(1):78-90.e3.
PMID: 39631396
Replication fork collision with a DNA nick can generate a one-ended break, fostering genomic instability. The opposing fork's collision with the nick could form a second DNA end, enabling conservative...
3.
Elango R, Nilavar N, Li A, Duffey E, Jiang Y, Nguyen D, et al.
bioRxiv
. 2024 Apr;
PMID: 38645103
Collision of a replication fork with a DNA nick is thought to generate a one-ended break, fostering genomic instability. Collision of the opposing converging fork with the nick could, in...
4.
Elango R, Panday A, Willis N, Scully R
STAR Protoc
. 2022 Aug;
3(3):101551.
PMID: 36042887
In this protocol, we use CRISPR/Cas9 to generate large deletions of the entire coding region of a gene of interest, generating a hemizygous cell line. Next, we systematically engineer precise...
5.
Elango R, Panday A, Lach F, Willis N, Nicholson K, Duffey E, et al.
Nat Struct Mol Biol
. 2022 Aug;
29(8):801-812.
PMID: 35941380
Vertebrate replication forks arrested at interstrand DNA cross-links (ICLs) engage the Fanconi anemia pathway to incise arrested forks, 'unhooking' the ICL and forming a double strand break (DSB) that is...
6.
Panday A, Elango R, Willis N, Scully R
STAR Protoc
. 2022 Aug;
3(3):101529.
PMID: 35928003
Chromatin immunoprecipitation coupled with quantitative PCR (ChIP-qPCR) even with optimization may give low signal-to-background ratio and spatial resolution. Here, we adapted Cleavage Under Targets and Release Using Nuclease (CUT&RUN) (originally...
7.
Adeyemi R, Willis N, Elia A, Clairmont C, Li S, Wu X, et al.
Mol Cell
. 2021 Oct;
81(21):4440-4456.e7.
PMID: 34597596
Protection of stalled replication forks is critical to genomic stability. Using genetic and proteomic analyses, we discovered the Protexin complex containing the ssDNA binding protein SCAI and the DNA polymerase...
8.
Scully R, Elango R, Panday A, Willis N
Curr Opin Genet Dev
. 2021 Aug;
71:154-162.
PMID: 34464818
Replication fork stalling occurs when the replisome encounters a barrier to normal fork progression. Replisome stalling events are common during scheduled DNA synthesis, but vary in their severity. At one...
9.
Panday A, Willis N, Elango R, Menghi F, Duffey E, Liu E, et al.
Mol Cell
. 2021 Apr;
81(11):2428-2444.e6.
PMID: 33882298
Repair pathway "choice" at stalled mammalian replication forks is an important determinant of genome stability; however, the underlying mechanisms are poorly understood. FANCM encodes a multi-domain scaffolding and motor protein...
10.
Willis N, Scully R
Methods Mol Biol
. 2020 Aug;
2153:329-353.
PMID: 32840790
Site-specific replication fork barriers (RFBs) have proven valuable tools for studying mechanisms of repair at sites of replication fork stalling in prokaryotes and yeasts. We adapted the Escherichia coli Tus-Ter...