R A Chandraratna
Overview
Explore the profile of R A Chandraratna including associated specialties, affiliations and a list of published articles.
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89
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1512
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Recent Articles
1.
Standeven A, Thacher S, Yuan Y, Escobar M, Vuligonda V, BEARD R, et al.
Biochem Pharmacol
. 2001 Dec;
62(11):1501-9.
PMID: 11728386
Hypertriglyceridemia is a major side-effect of retinoid therapy in humans. We previously reported that agonists for the retinoic acid receptors (RARs), but not the retinoid X receptors (RXRs), elevate serum...
2.
Nagpal S, Ghosn C, Chandraratna R
Methods Mol Biol
. 2001 Sep;
176:359-76.
PMID: 11554336
No abstract available.
3.
Koide T, Downes M, Chandraratna R, Blumberg B, Umesono K
Genes Dev
. 2001 Aug;
15(16):2111-21.
PMID: 11511542
The retinoic acid receptors (RARs) recruit coactivator and corepressor proteins to activate or repress the transcription of target genes depending on the presence of retinoic acid (RA). Despite a detailed...
4.
Hammond L, Van Krinks C, Durham J, Tomkins S, Burnett R, Jones E, et al.
Br J Cancer
. 2001 Aug;
85(3):453-62.
PMID: 11487280
Novel synthetic antagonists of retinoic acid receptors (RARs) have been developed. To avoid interference by serum retinoids when testing these compounds, we established serum-free grown sub-lines (>3 years) of the...
5.
Thacher S, Vasudevan J, Tsang K, Nagpal S, Chandraratna R
J Med Chem
. 2001 Jul;
44(3):281-97.
PMID: 11462969
No abstract available.
6.
Soprano D, Gambone C, Sheikh S, Gabriel J, Chandraratna R, Soprano K, et al.
Toxicol Appl Pharmacol
. 2001 Jul;
174(2):153-9.
PMID: 11446831
The synthetic retinoid AGN 193109 is a potent pan retinoic acid receptor (RAR) antagonist. Treatment of pregnant mice with a single oral 1 mg/kg dose of this antagonist on day...
7.
Vuligonda V, Thacher S, Chandraratna R
J Med Chem
. 2001 Jun;
44(14):2298-303.
PMID: 11428923
The synthesis and characterization of chiral RXR selective ligands are described. The enantiomeric acids 2 and 3 were synthesized employing an enantioselective cylopropanation procedure as the key step. Compound 2,...
8.
Zang Y, BEARD R, Chandraratna R, Kang J
Cell Death Differ
. 2001 Jun;
8(5):477-85.
PMID: 11423908
The novel synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid (AHPN/CD437) has been proven to be a potent inducer of apoptosis in a variety of tumor cell types. However, the mechanism of its...
9.
Samuel W, Kutty R, Nagineni S, Gordon J, Prouty S, Chandraratna R, et al.
J Biol Chem
. 2001 Jun;
276(31):28744-50.
PMID: 11397803
Stearoyl-CoA desaturase (SCD) is a regulatory enzyme involved in the synthesis of the monounsaturated fatty acids palmitoleate and oleate. The regulation of SCD is of physiological importance because the ratio...
10.
Wakino S, Kintscher U, Kim S, Jackson S, Yin F, Nagpal S, et al.
Arterioscler Thromb Vasc Biol
. 2001 May;
21(5):746-51.
PMID: 11348869
Retinoids inhibit rat vascular smooth muscle cell (VSMC) proliferation in vitro and intimal hyperplasia in vivo. We examined the mechanism of the antiproliferative effect of retinoids on human coronary artery...