R A HEYMAN
Overview
Explore the profile of R A HEYMAN including associated specialties, affiliations and a list of published articles.
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Articles
86
Citations
4481
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Recent Articles
1.
Michellys P, Ardecky R, Chen J, Crombie D, Etgen G, Faul M, et al.
J Med Chem
. 2003 Jun;
46(13):2683-96.
PMID: 12801232
Previous data have shown that RXR-selective agonists (e.g., 3 and 4) are insulin sensitizers in rodent models of non-insulin-dependent diabetes mellitus (NIDDM). Unfortunately, they also produce dramatic increases in triglycerides...
2.
Cesario R, Klausing K, Razzaghi H, CROMBIE D, Rungta D, HEYMAN R, et al.
Mol Endocrinol
. 2001 Jul;
15(8):1360-9.
PMID: 11463859
The RXR serves as a heterodimer partner for the PPARgamma and the dimer is a molecular target for insulin sensitizers such as the thiazolidinediones. Ligands for either receptor can activate...
3.
Singh Ahuja H, Liu S, Crombie D, Boehm M, Leibowitz M, HEYMAN R, et al.
Mol Pharmacol
. 2001 Mar;
59(4):765-73.
PMID: 11259621
Both retinoid X receptor (RXR)-selective agonists (rexinoids) and thiazolidinediones (TZDs), PPAR (peroxisome proliferator-activated receptor)-gamma-specific ligands, produce insulin sensitization in diabetic rodents. In vitro studies have demonstrated that TZDs mediate their...
4.
Claudel T, Leibowitz M, Fievet C, Tailleux A, Wagner B, REPA J, et al.
Proc Natl Acad Sci U S A
. 2001 Feb;
98(5):2610-5.
PMID: 11226287
A common feature of many metabolic pathways is their control by retinoid X receptor (RXR) heterodimers. Dysregulation of such metabolic pathways can lead to the development of atherosclerosis, a disease...
5.
Davies P, Berry S, Shipley G, Eckel R, Hennuyer N, Crombie D, et al.
Mol Pharmacol
. 2001 Feb;
59(2):170-6.
PMID: 11160850
Hypertriglyceridemia is a frequent complication accompanying the treatment of patients with either retinoids or rexinoids, [retinoid X receptor (RXR)-selective retinoids]. To investigate the cellular and molecular basis for this observation,...
6.
REPA J, Turley S, Lobaccaro J, Medina J, Li L, Lustig K, et al.
Science
. 2000 Sep;
289(5484):1524-9.
PMID: 10968783
Several nuclear hormone receptors involved in lipid metabolism form obligate heterodimers with retinoid X receptors (RXRs) and are activated by RXR agonists such as rexinoids. Animals treated with rexinoids exhibited...
7.
Liu Y, Sennitt M, Hislop D, Crombie D, HEYMAN R, Cawthorne M
Int J Obes Relat Metab Disord
. 2000 Aug;
24(8):997-1004.
PMID: 10951538
Objective: To investigate whether retinoid X receptor agonists act as insulin sensitizers and compare their effects with that of thiazolidinedione BRL 49653 in obese Zucker rats. Design: In two independent...
8.
Shao G, HEYMAN R, Schulman I
Mol Endocrinol
. 2000 Aug;
14(8):1198-209.
PMID: 10935544
Binding of agonists to nuclear receptors results in a conformational change in receptor structure that promotes interaction between activated receptors and coactivators. Receptor-coactivator interactions are mediated by the agonist-dependent formation...
9.
Sun S, Yue P, Mao L, Dawson M, Shroot B, Lamph W, et al.
Clin Cancer Res
. 2000 Apr;
6(4):1563-73.
PMID: 10778990
Retinoids modulate the growth and differentiation of cancer cells presumably by activating gene transcription via the nuclear retinoic acid receptor (RAR) alpha, beta, and gamma and retinoid X receptor (RXR)...
10.
Martin G, Poirier H, Hennuyer N, CROMBIE D, Fruchart J, HEYMAN R, et al.
J Biol Chem
. 2000 Apr;
275(17):12612-8.
PMID: 10777552
The intracellular fatty acid content of insulin-sensitive target tissues determines in part their insulin sensitivity. Uptake of fatty acids into cells is a controlled process determined in part by a...