E S Klein
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Explore the profile of E S Klein including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
210
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Recent Articles
1.
Klein E, Barbier M, Watson J
R Soc Open Sci
. 2017 Sep;
4(8):170740.
PMID: 28879013
Understanding how and when cooperative human behaviour forms in common-pool resource systems is critical to illuminating social-ecological systems and designing governance institutions that promote sustainable resource use. Before assessing the...
2.
Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity
BEARD R, Klein E, Standeven A, Escobar M, Chandraratna R
Bioorg Med Chem Lett
. 2001 Mar;
11(6):765-8.
PMID: 11277515
Retinoids are natural and synthetic analogues of the hormone retinoic acid. Systemic retinoid agonist therapy is usually associated with toxic side effects, such as mucocutaneous toxicity, which may be alleviated...
3.
Klein E, Wang J, Khalifa B, Gavigan S, Chandraratna R
J Biol Chem
. 2000 Apr;
275(25):19401-8.
PMID: 10777502
Ligand activation of retinoic acid receptors (RARs) involves coordinated changes in their interaction with coregulatory molecules. Binding of the agonist all-trans-retinoic acid to the RAR results in increased interaction with...
4.
Nagpal S, Ghosn C, DiSepio D, Molina Y, Sutter M, Klein E, et al.
J Biol Chem
. 1999 Jul;
274(32):22563-8.
PMID: 10428834
Targeted recruitment of histone acetyltransferase (HAT) activities by sequence-specific transcription factors, including the retinoic acid receptors (RARs) and retinoid X receptors (RXRs), has been proposed to lead to destabilization of...
5.
Thacher S, Nagpal S, Klein E, Arefieg T, Krasinski G, DiSepio D, et al.
Cell Growth Differ
. 1999 May;
10(4):255-62.
PMID: 10319995
Retinoids are important regulators of epithelial differentiation. AGN 193109 is a high-affinity antagonist and inverse agonist for the nuclear retinoic acid receptors (RARs). Paradoxically, both AGN 193109 and retinoid agonists...
6.
Teng M, Duong T, Johnson A, Klein E, Wang L, Khalifa B, et al.
J Med Chem
. 1997 Aug;
40(16):2445-51.
PMID: 9258350
The syntheses and full retinoid receptor characterization of a novel series of retinoic acid receptor alpha (RAR alpha) antagonists, 1-5, are described. These compounds bind with high affinity to RAR...
7.
Johnson A, Klein E, Wang L, PINO M, Chandraratna R
J Med Chem
. 1996 Dec;
39(26):5027-30.
PMID: 8978832
No abstract available.
8.
Klein E, PINO M, Johnson A, Davies P, Nagpal S, Thacher S, et al.
J Biol Chem
. 1996 Sep;
271(37):22692-6.
PMID: 8798442
Inverse agonists are ligands that are capable of repressing basal receptor activity in the absence of an agonist. We have designed a series of C-1-substituted acetylenic retinoids that exhibit potent...
9.
Teng M, Duong T, Klein E, PINO M, Chandraratna R
J Med Chem
. 1996 Aug;
39(16):3035-8.
PMID: 8759622
No abstract available.
10.
Klein E, Asculai S
J Surg Res
. 1996 Mar;
61(2):473-6.
PMID: 8656628
The process of intraperitoneal adhesion formation is affected by macrophages and fibroblasts which are major components of postsurgical peritoneal repair. Hyaluronic acid (HA) has been shown to affect cellular behavior....