Agata Nawrotek
Overview
Explore the profile of Agata Nawrotek including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
269
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Recent Articles
1.
Nawrotek A, Dubois P, Zeghouf M, Cherfils J
FEBS Lett
. 2023 Jan;
597(6):778-793.
PMID: 36700390
Most small GTPases actuate their functions on subcellular membranes, which are increasingly seen as integral components of small GTPase signalling. In this review, we used the highly studied regulation of...
2.
Kiyeleko S, Hocine S, Mautino G, Kuenemann M, Nawrotek A, Miallau L, et al.
Bioorg Med Chem Lett
. 2022 Aug;
75:128950.
PMID: 36030002
We describe the synthesis of a series of 3-t-butyl 5-aminopyrazole p-substituted arylamides as inhibitors of serine-threonine25 (STK25), an enzyme implicated in the progression of non-alcoholic fatty liver disease (NAFLD). Appending...
3.
Nawrotek A, Cherfils J
Med Sci (Paris)
. 2021 Apr;
37(4):372-378.
PMID: 33908855
mTORC1 is a central player in cell growth, a process that is tightly regulated by the availability of nutrients and that controls various aspects of metabolism in the normal cell...
4.
Adams S, Purkiss A, Knowles P, Nans A, Briggs D, Borg A, et al.
Structure
. 2021 Jan;
29(7):694-708.e7.
PMID: 33484636
RET receptor tyrosine kinase plays vital developmental and neuroprotective roles in metazoans. GDNF family ligands (GFLs) when bound to cognate GFRα co-receptors recognize and activate RET stimulating its cytoplasmic kinase...
5.
Nawrotek A, Zeghouf M, Cherfils J
Biochem Soc Trans
. 2020 Dec;
48(6):2721-2728.
PMID: 33336699
Small GTPases, in association with their GEFs, GAPs and effectors, control major intracellular processes such as signal transduction, cytoskeletal dynamics and membrane trafficking. Accordingly, dysfunctions in their biochemical properties are...
6.
Das S, Malaby A, Nawrotek A, Zhang W, Zeghouf M, Maslen S, et al.
Structure
. 2019 Oct;
27(12):1782-1797.e7.
PMID: 31601460
Membrane dynamic processes require Arf GTPase activation by guanine nucleotide exchange factors (GEFs) with a Sec7 domain. Cytohesin family Arf GEFs function in signaling and cell migration through Arf GTPase...
7.
Nawrotek A, Benabdi S, Niyomchon S, Kryszke M, Ginestier C, Caneque T, et al.
Nat Chem Biol
. 2019 Mar;
15(5):549.
PMID: 30833779
In the version of this article originally published, several co-authors had incorrect affiliation footnote numbers listed in the author list. Tatiana Cañeque and Angelica Mariani should each have affiliation numbers...
8.
Nawrotek A, Benabdi S, Niyomchon S, Kryszke M, Ginestier C, Caneque T, et al.
Nat Chem Biol
. 2019 Feb;
15(4):358-366.
PMID: 30742123
Peripheral membrane proteins orchestrate many physiological and pathological processes, making regulation of their activities by small molecules highly desirable. However, they are often refractory to classical competitive inhibition. Here, we...
9.
Karandur D, Nawrotek A, Kuriyan J, Cherfils J
Proc Natl Acad Sci U S A
. 2017 Sep;
114(43):11416-11421.
PMID: 28923919
Lipidated small GTPases and their regulators need to bind to membranes to propagate actions in the cell, but an integrated understanding of how the lipid bilayer exerts its effect has...
10.
Benabdi S, Peurois F, Nawrotek A, Chikireddy J, Caneque T, Yamori T, et al.
Biochemistry
. 2017 Sep;
56(38):5125-5133.
PMID: 28858527
Arf GTPases and their guanine nucleotide exchange factors (ArfGEFs) are major regulators of membrane traffic and organelle structure in cells. They are associated with a variety of diseases and are...