Peter Humphries
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Explore the profile of Peter Humphries including associated specialties, affiliations and a list of published articles.
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77
Citations
2425
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Recent Articles
21.
Doyle S, Adamson P, Lopez F, Humphries P, Campbell M
Nat Med
. 2014 Dec;
20(12):1376-7.
PMID: 25473915
No abstract available.
22.
Campbell M, Doyle S, Humphries P
Expert Rev Clin Immunol
. 2014 Aug;
10(10):1273-5.
PMID: 25142147
Recent evidence suggests that the pro-inflammatory cytokine IL-18 may have utility as an anti-angiogenic agent in the eye. Numerous laboratories, including our own have demonstrated the ability of murine IL-18...
23.
Doyle S, Ozaki E, Brennan K, Humphries M, Mulfaul K, Keaney J, et al.
Sci Transl Med
. 2014 Apr;
6(230):230ra44.
PMID: 24695684
Age-related macular degeneration (AMD) is the most common form of central retinal blindness globally. Distinct processes of the innate immune system, specifically activation of the NLRP3 inflammasome, have been shown...
24.
Kiang A, Humphries M, Campbell M, Humphries P
Adv Exp Med Biol
. 2014 Mar;
801:783-9.
PMID: 24664771
Disease mechanisms associated with retinal disease are of immense complexity, mutations within 45 genes having been implicated, for example, in retinitis pigmentosa, while interplay between genetic, environmental, and demographic factors...
25.
Nguyen A, Campbell M, Kiang A, Humphries M, Humphries P
Adv Exp Med Biol
. 2014 Mar;
801:471-6.
PMID: 24664733
The first autosomal dominant mutation identified to cause retinitis pigmentosa in the North American population was the substitution of proline to histidine at position 23 of the rhodopsin gene (P23H...
26.
Campbell M, Doyle S, Ozaki E, Kenna P, Kiang A, Humphries M, et al.
Adv Exp Med Biol
. 2014 Mar;
801:409-15.
PMID: 24664725
Age-related macular degeneration (AMD) is the leading cause of central vision loss worldwide and while polymorphisms in genes associated with the immune system have been identified as risk factors for...
27.
Ozaki E, Campbell M, Kiang A, Humphries M, Doyle S, Humphries P
Adv Exp Med Biol
. 2014 Mar;
801:229-35.
PMID: 24664703
Age-related macular degeneration (AMD) is the leading cause of legal blindness in elderly individuals in the developed world, affecting 30-50 million people worldwide. AMD primarily affects the macular region of...
28.
Daiger S, Bowne S, Sullivan L, Blanton S, Weinstock G, Koboldt D, et al.
Adv Exp Med Biol
. 2014 Mar;
801:123-9.
PMID: 24664689
The goal of our research is to identify genes and mutations causing autosomal dominant retinitis pigmentosa (adRP). For this purpose we established a cohort of more than 250 independently ascertained...
29.
Tanimoto N, Sothilingam V, Gloeckner G, Bryda E, Humphries P, Biel M, et al.
Doc Ophthalmol
. 2013 Nov;
128(1):25-32.
PMID: 24221507
Purpose: In murine disease models, particularly in cases when retinal electrical activity is reduced, an event-related component becomes apparent that does not change with the stimulus intensity in electroretinogram (ERG)...
30.
Campbell M, Humphries P
Adv Exp Med Biol
. 2013 Feb;
763:70-84.
PMID: 23397619
The blood-retina barrier (BRB) is composed of both an inner and an outer barrier. The outer BRB refers to the barrier formed at the retinal pigment epithelial (RPE) cell layer...