Reply to IL-18 is Not Therapeutic for Neovascular Age-related Macular Degeneration

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2014 Dec 5

PMID 25473915

Citations 7

Authors

Sarah L Doyle

Peter Adamson

Francisco J Lopez

Peter Humphries

Matthew Campbell

Affiliations

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Citing Articles

The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome.

Brandli A, Vessey K, Fletcher E J Neuroinflammation. 2024; 21(1):64.

PMID: 38443987 PMC: 10913318. DOI: 10.1186/s12974-024-03055-1.

Chronic, Systemic Interleukin-18 Does Not Promote Macular Degeneration or Choroidal Neovascularization.

Canna S, Shi G, Gery I, Sen H Invest Ophthalmol Vis Sci. 2017; 58(3):1764-1765.

PMID: 28334374 PMC: 5374878. DOI: 10.1167/iovs.17-21697.

THE PATHOPHYSIOLOGY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION AND THE COMPLEMENT PATHWAY AS A THERAPEUTIC TARGET.

Boyer D, Schmidt-Erfurth U, van Lookeren Campagne M, Henry E, Brittain C Retina. 2016; 37(5):819-835.

PMID: 27902638 PMC: 5424580. DOI: 10.1097/IAE.0000000000001392.

Friend or Foe? Resident Microglia vs Bone Marrow-Derived Microglia and Their Roles in the Retinal Degeneration.

Jin N, Gao L, Fan X, Xu H Mol Neurobiol. 2016; 54(6):4094-4112.

PMID: 27318678 DOI: 10.1007/s12035-016-9960-9.

Inflammation and its role in age-related macular degeneration.

Kauppinen A, Paterno J, Blasiak J, Salminen A, Kaarniranta K Cell Mol Life Sci. 2016; 73(9):1765-86.

PMID: 26852158 PMC: 4819943. DOI: 10.1007/s00018-016-2147-8.

References

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Hirano Y, Yasuma T, Mizutani T, Fowler B, Tarallo V, Yasuma R . IL-18 is not therapeutic for neovascular age-related macular degeneration. Nat Med. 2014; 20(12):1372-5. PMC: 4275546. DOI: 10.1038/nm.3671. View

Qiao H, Sonoda K, Ikeda Y, Yoshimura T, Hijioka K, Jo Y . Interleukin-18 regulates pathological intraocular neovascularization. J Leukoc Biol. 2007; 81(4):1012-21. DOI: 10.1189/jlb.0506342. View

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Marneros A . NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration. Cell Rep. 2013; 4(5):945-58. PMC: 3821550. DOI: 10.1016/j.celrep.2013.08.002. View

Doyle S, Campbell M, Ozaki E, Salomon R, Mori A, Kenna P . NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat Med. 2012; 18(5):791-8. PMC: 3984677. DOI: 10.1038/nm.2717. View

10.

Shen J, Choy D, Yoshida T, Iwase T, Hafiz G, Xie B . Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: reciprocal suppression with VEGF. J Cell Physiol. 2014; 229(8):974-83. PMC: 4364659. DOI: 10.1002/jcp.24575. View