Peter Humphries
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Explore the profile of Peter Humphries including associated specialties, affiliations and a list of published articles.
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77
Citations
2425
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Recent Articles
11.
Hanlon K, Chadderton N, Palfi A, Blanco Fernandez A, Humphries P, Kenna P, et al.
Front Neurosci
. 2017 Oct;
11:521.
PMID: 28983234
Significant advances in gene therapy have enabled exploration of therapies for inherited retinal disorders, many of which are in preclinical development or clinical evaluation. Gene therapy for retinal conditions has...
12.
OCallaghan J, Crosbie D, Cassidy P, Sherwood J, Flugel-Koch C, Lutjen-Drecoll E, et al.
Hum Mol Genet
. 2017 Feb;
26(7):1230-1246.
PMID: 28158775
Intraocular pressure (IOP) is maintained as a result of the balance between production of aqueous humour (AH) by the ciliary processes and hydrodynamic resistance to its outflow through the conventional...
13.
Carrigan M, Duignan E, Malone C, Stephenson K, Saad T, McDermott C, et al.
Sci Rep
. 2016 Sep;
6:33248.
PMID: 27624628
Inherited retinopathies affect approximately two and a half million people globally, yet the majority of affected patients lack clear genetic diagnoses given the diverse range of genes and mutations implicated...
14.
Palfi A, Chadderton N, OReilly M, Nagel-Wolfrum K, Wolfrum U, Bennett J, et al.
Mol Ther Methods Clin Dev
. 2016 Jun;
3:16032.
PMID: 27257610
[This corrects the article DOI: 10.1038/mtm.2015.16.].
15.
Doyle S, Lopez F, Humphries P, Adamson P, Campbell M
Invest Ophthalmol Vis Sci
. 2016 Jan;
56(13):8237-8.
PMID: 26720477
No abstract available.
16.
Keaney J, Walsh D, OMalley T, Hudson N, Crosbie D, Loftus T, et al.
Sci Adv
. 2015 Oct;
1(8):e1500472.
PMID: 26491725
The blood-brain barrier (BBB) is essential for maintaining brain homeostasis and protecting neural tissue from damaging blood-borne agents. The barrier is characterized by endothelial tight junctions that limit passive paracellular...
17.
Doyle S, Lopez F, Celkova L, Brennan K, Mulfaul K, Ozaki E, et al.
Invest Ophthalmol Vis Sci
. 2015 Aug;
56(9):5424-30.
PMID: 26284546
Purpose: Age-related macular degeneration is the most common form of central retinal blindness in the elderly. Of the two end stages of disease, neovascular AMD-although the minority form-is the most...
18.
Tanimoto N, Sothilingam V, Kondo M, Biel M, Humphries P, Seeliger M
Sci Rep
. 2015 Jun;
5:10731.
PMID: 26029863
Mouse full-field electroretinograms (ERGs) are dominated by responses of photoreceptors and depolarizing (ON-) bipolar cells, but not much of hyperpolarizing (OFF-) bipolar cells under conventional recording conditions. Here we investigate...
19.
Palfi A, Chadderton N, OReilly M, Nagel-Wolfrum K, Wolfrum U, Bennett J, et al.
Mol Ther Methods Clin Dev
. 2015 Jun;
2:15016.
PMID: 26029727
As gene therapies for various forms of retinal degeneration progress toward human clinical trial, it will be essential to have a repertoire of safe and efficient vectors for gene delivery...
20.
Doyle S, Adamson P, Lopez F, Humphries P, Campbell M
Invest Ophthalmol Vis Sci
. 2014 Dec;
55(12):8349-50.
PMID: 25538010
No abstract available.