Peter Giles
Overview
Explore the profile of Peter Giles including associated specialties, affiliations and a list of published articles.
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20
Citations
408
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0
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Recent Articles
1.
Tee A, Jones R, Dunlop E, Champion J, Doubleday P, Claessens T, et al.
Res Sq
. 2024 Jul;
PMID: 38978568
Birt-Hogg-Dubé (BHD) syndrome patients are uniquely susceptible to all renal tumour subtypes. The underlying mechanism of carcinogenesis is unclear. To study cancer development in BHD, we used human proximal kidney...
2.
Meuser E, Chang K, Walters A, Hurley J, West H, Perry I, et al.
Mol Cancer Res
. 2024 Mar;
22(6):515-523.
PMID: 38546397
Implications: PIGA somatic mutation in duodenal tumors from patients with FAP and MAP and loss of membrane GPI-anchors may present new opportunities for understanding and intervention in duodenal tumorigenesis.
3.
Shephard A, Giles P, Mbengue M, Alraies A, Spary L, Kynaston H, et al.
J Extracell Vesicles
. 2021 Oct;
10(12):e12150.
PMID: 34596356
Histological assessment of prostate cancer is the key diagnostic test and can predict disease outcome. This is however an invasive procedure that carries associated risks, hence non-invasive assays to support...
4.
Ordonez L, Melchor L, Greenow K, Kendrick H, Tornillo G, Bradford J, et al.
Dis Model Mech
. 2021 May;
14(5).
PMID: 34003256
Understanding the mechanisms underlying tumour heterogeneity is key to the development of treatments that can target specific tumour subtypes. We have previously targeted CRE recombinase-dependent conditional deletion of the tumour...
5.
Lawson H, Sepulveda C, van de Lagemaat L, Durko J, Barile M, Tavosanis A, et al.
Blood Adv
. 2021 Feb;
5(3):889-899.
PMID: 33560400
Lifelong multilineage hematopoiesis critically depends on rare hematopoietic stem cells (HSCs) that reside in the hypoxic bone marrow microenvironment. Although the role of the canonical oxygen sensor hypoxia-inducible factor prolyl...
6.
Almotiri A, Alzahrani H, Menendez-Gonzalez J, Abdelfattah A, Alotaibi B, Saleh L, et al.
J Clin Invest
. 2020 Oct;
131(1).
PMID: 33108352
Zeb1, a zinc finger E-box binding homeobox epithelial-mesenchymal transition (EMT) transcription factor, confers properties of "stemness," such as self-renewal, in cancer. Yet little is known about the function of Zeb1...
7.
Holzhauser S, Pirotte E, Jones J, Owens D, Al-Hussaini A, Giles P, et al.
Oncol Rep
. 2020 Sep;
44(4):1717-1726.
PMID: 32945506
Human papillomavirus‑positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) has increased in incidence and has a much better prognosis than HPV‑negative (HPV‑) OPSCC with radiotherapy alone, but exactly why is unknown....
8.
Short E, Thomas L, Davies A, Bolton A, Maynard J, Giles P, et al.
Eur J Hum Genet
. 2019 Aug;
28(1):118-121.
PMID: 31383941
Familial adenomatous polyposis (FAP) is characterised by the development of hundreds to thousands of colorectal adenomas and results from inherited or somatic mosaic variants in the APC gene. Index patients...
9.
Menendez-Gonzalez J, Vukovic M, Abdelfattah A, Saleh L, Almotiri A, Thomas L, et al.
Stem Cell Reports
. 2019 Aug;
13(2):291-306.
PMID: 31378673
Subversion of transcription factor (TF) activity in hematopoietic stem/progenitor cells (HSPCs) leads to the development of therapy-resistant leukemic stem cells (LSCs) that drive fulminant acute myeloid leukemia (AML). Using a...
10.
Caley M, Wall I, Peake M, Kipling D, Giles P, Thomas D, et al.
Int J Mol Sci
. 2018 Mar;
19(4).
PMID: 29584680
: Chronic skin wounds are a growing financial burden for healthcare providers, causing discomfort/immobility to patients. Whilst animal chronic wound models have been developed to allow for mechanistic studies and...