Neil P Rodrigues
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Explore the profile of Neil P Rodrigues including associated specialties, affiliations and a list of published articles.
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28
Citations
1059
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Recent Articles
1.
Almotiri A, Abogosh A, Abdelfattah A, Alowaisy D, Rodrigues N
Mol Ther
. 2025 Jan;
PMID: 39827371
In the setting of monogenic disease, advances made in genome editing technologies can, in principle, be deployed as a therapeutic strategy to precisely correct a specific gene mutation in an...
2.
Almotiri A, Abdelfattah A, Storch E, Stemmler M, Brabletz S, Brabletz T, et al.
Exp Hematol
. 2024 Feb;
134:104177.
PMID: 38336135
Emerging evidence implicates the epithelial-mesenchymal transition transcription factor Zeb1 as a critical regulator of hematopoietic stem cell (HSC) differentiation. Whether Zeb1 regulates long-term maintenance of HSC function remains an open...
3.
Almotiri A, Boyd A, Rodrigues N
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759786
, a zinc finger E-box binding homeobox epithelial-mesenchymal (EMT) transcription factor, acts as a critical regulator of hematopoietic stem cell (HSC) self-renewal and multi-lineage differentiation. Whether directly regulates the function...
4.
Chan Y, Moss J, Williams J, Ferekidis N, AlShehri N, Hughes T, et al.
Mol Nutr Food Res
. 2023 May;
67(14):e2200716.
PMID: 37150886
Scope: A prospective study of 34492 participants shows an inverse association between (+)-catechin intake and coronary heart disease. The effects of (+)-catechin on atherosclerosis and associated risk factors are poorly...
5.
Rastogi N, Gonzalez J, Srivastava V, Alanazi B, Alanazi R, Hughes O, et al.
Leukemia
. 2022 Dec;
37(2):276-287.
PMID: 36572750
Nuclear factor I-C (NFIC) belongs to a family of NFI transcription factors that binds to DNA through CAATT-boxes and are involved in cellular differentiation and stem cell maintenance. Here we...
6.
Almotiri A, Abdelfattah A, Rodrigues N
Methods Mol Biol
. 2022 Mar;
2419:583-595.
PMID: 35237990
Advancing age causes physiologic decline in tissue function. In the hematopoietic system this manifests as a progressive reduction in blood or immune cell function and clonal hematopoiesis, where a mutated...
7.
Menendez-Gonzalez J, Rodrigues N
Methods Mol Biol
. 2022 Mar;
2419:73-88.
PMID: 35237959
Outgrowth of a mutated hematopoietic stem/progenitor clone and its descendants, also known as clonal hematopoiesis, has long been considered as either a potential forerunner to hematologic malignancy or as a...
8.
Lawson H, van de Lagemaat L, Barile M, Tavosanis A, Durko J, Villacreces A, et al.
Stem Cell Reports
. 2021 Oct;
16(11):2784-2797.
PMID: 34715054
Hematopoietic stem cells (HSCs) reside at the apex of the hematopoietic differentiation hierarchy and sustain multilineage hematopoiesis. Here, we show that the transcriptional regulator CITED2 is essential for life-long HSC...
9.
Abdelfattah A, Hughes-Davies A, Clayfield L, Menendez-Gonzalez J, Almotiri A, Alotaibi B, et al.
Blood Adv
. 2021 Sep;
5(20):4285-4290.
PMID: 34496012
During aging, hematopoietic stem cell (HSC) function wanes with important biological and clinical implications for benign and malignant hematology, and other comorbidities, such as cardiovascular disease. However, the molecular mechanisms...
10.
OMorain V, Chan Y, Williams J, Alotibi R, Alahmadi A, Rodrigues N, et al.
Mol Nutr Food Res
. 2021 Jul;
65(17):e2100214.
PMID: 34216185
Scope: Previous studies show that Lab4 probiotic consortium plus Lactobacillus plantarum CUL66 (Lab4P) reduces diet-induced weight gain and plasma cholesterol levels in C57BL/6J mice fed a high fat diet (HFD)....