Pavel Kovarik
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Explore the profile of Pavel Kovarik including associated specialties, affiliations and a list of published articles.
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47
Citations
1853
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Recent Articles
1.
Wang L, He L, Xiong X, Wu Z, Tian M, Cao G, et al.
Acta Pharmacol Sin
. 2025 Jan;
PMID: 39890944
Platelet-derived growth factor (PDGF-BB) released from the injured intima induces the proliferation and migration of vascular smooth muscle cells (VSMCs), which is the key mechanism of neointimal hyperplasia. Zinc finger...
2.
Bestehorn A, von Wiren J, Zeiler C, Fesselet J, Didusch S, Forte M, et al.
Mol Cell
. 2025 Jan;
85(4):742-755.e9.
PMID: 39862867
The fidelity of immune responses depends on timely controlled and selective mRNA degradation that is largely driven by RNA-binding proteins (RBPs). It remains unclear whether stochastic or directed processes govern...
3.
Hu Y, Hai J, Ti Y, Kong B, Yao G, Zhao Y, et al.
Metabolism
. 2025 Jan;
164:156131.
PMID: 39761791
Aims: Obesity, as a worldwide healthcare problem, has become more prevalent. ZFP36 is a well-known RNA-binding protein and involved in the posttranscriptional regulation of many physiological processes. Whether the adipose...
4.
Cui X, Wang Y, Lu H, Wang L, Xie X, Zhang S, et al.
Adv Sci (Weinh)
. 2024 Nov;
12(3):e2408811.
PMID: 39589932
Hypertension remains a major risk factor for cardiovascular diseases, but the underlying mechanisms are not well understood. Zinc finger protein 36 (ZFP36) is an RNA-binding protein that regulates mRNA stability...
5.
Scinicariello S, Soderholm A, Schafer M, Shulkina A, Schwartz I, Hacker K, et al.
Elife
. 2023 Mar;
12.
PMID: 36961408
Tristetraprolin (TTP) is a critical negative immune regulator. It binds AU-rich elements in the untranslated-regions of many mRNAs encoding pro-inflammatory mediators, thereby accelerating their decay. A key but poorly understood...
6.
Boccuni L, Podgorschek E, Schmiedeberg M, Platanitis E, Traxler P, Fischer P, et al.
Sci Signal
. 2022 Dec;
15(764):eabq5389.
PMID: 36512641
Promoters of antimicrobial genes function as logic boards, integrating signals of innate immune responses. One such set of genes is stimulated by interferon (IFN) signaling, and the expression of these...
7.
Eislmayr K, Bestehorn A, Morelli L, Borroni M, Vande Walle L, Lamkanfi M, et al.
Sci Adv
. 2022 Mar;
8(9):eabj7293.
PMID: 35235356
Interleukin-1α (IL-1α) and IL-1β are inflammatory cytokines with important roles in health and disease. They trigger the same receptor and elicit comparable cellular responses but, for poorly understood reasons, are...
8.
Gomez-Diaz C, Jonsson G, Schodl K, Deszcz L, Bestehorn A, Eislmayr K, et al.
iScience
. 2021 Nov;
24(11):103241.
PMID: 34755089
The Linear Ubiquitin Chain Assembly Complex (LUBAC), composed of HOIP, HOIL-1L, and SHARPIN, promotes tumor necrosis factor (TNF)-dependent NF-κB signaling in diverse cell types. HOIL-1L contains an Npl4 Zinc Finger...
9.
Kovarik P, Bestehorn A, Fesselet J
Front Immunol
. 2021 Oct;
12:751313.
PMID: 34603339
Regulated changes in mRNA stability are critical drivers of gene expression adaptations to immunological cues. mRNA stability is controlled mainly by RNA-binding proteins (RBPs) which can directly cleave mRNA but...
10.
Sneezum L, Eislmayr K, Dworak H, Sedlyarov V, Le Heron A, Ebner F, et al.
Front Immunol
. 2020 Aug;
11:1398.
PMID: 32733464
The bioavailability of the major pro-inflammatory cytokines IL-1α and IL-1β is tightly controlled by transcription and post-translational processing to prevent hyperinflammation. The role of mRNA decay in maintenance of physiological...