Pavel Kovarik
Overview
Explore the profile of Pavel Kovarik including associated specialties, affiliations and a list of published articles.
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47
Citations
1853
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Recent Articles
11.
Kralova J, Drobek A, Prochazka J, Spoutil F, Fabisik M, Glatzova D, et al.
J Immunol
. 2020 Feb;
204(6):1607-1620.
PMID: 32024700
Autoinflammatory diseases are characterized by dysregulation of the innate immune system, leading to spontaneous inflammation. mouse strain is a well-characterized model of this class of disorders. Because of the mutation...
12.
Steinparzer I, Sedlyarov V, Rubin J, Eislmayr K, Galbraith M, Levandowski C, et al.
Mol Cell
. 2019 Sep;
76(3):485-499.e8.
PMID: 31495563
Transcriptional responses to external stimuli remain poorly understood. Using global nuclear run-on followed by sequencing (GRO-seq) and precision nuclear run-on sequencing (PRO-seq), we show that CDK8 kinase activity promotes RNA...
13.
Hafner A, Kolbe U, Freund I, Castiglia V, Kovarik P, Poth T, et al.
Front Immunol
. 2019 Mar;
10:198.
PMID: 30846984
is a major human pathogen causing a variety of diseases ranging from common pharyngitis to life-threatening soft tissue infections and sepsis. Microbial nucleic acids, especially bacterial RNA, have recently been...
14.
Parrini M, Meissl K, Ola M, Lederer T, Puga A, Wienerroither S, et al.
Front Immunol
. 2018 Dec;
9:2879.
PMID: 30574148
STAT1 has a key role in the regulation of innate and adaptive immunity by inducing transcriptional changes in response to cytokines, such as all types of interferons (IFN). STAT1 exist...
15.
Beyer R, Jandric Z, Zutz C, Gregori C, Willinger B, Jacobsen I, et al.
Cell Microbiol
. 2018 Aug;
20(12):e12943.
PMID: 30112857
Candida glabrata is a common human fungal commensal and opportunistic pathogen. This fungus shows remarkable resilience as it can form recalcitrant biofilms on indwelling catheters, has intrinsic resistance against azole...
16.
Sedlyarov V, Eichner R, Girardi E, Essletzbichler P, Goldmann U, Nunes-Hasler P, et al.
Cell Host Microbe
. 2018 May;
23(6):766-774.e5.
PMID: 29779931
Macrophages represent the first line of immune defense against pathogens, and phagosome acidification is a necessary step in pathogen clearance. Here, we identified the bicarbonate transporter SLC4A7, which is strongly...
17.
Ivin M, Dumigan A, de Vasconcelos F, Ebner F, Borroni M, Kavirayani A, et al.
PLoS Pathog
. 2017 Nov;
13(11):e1006696.
PMID: 29112952
Klebsiella pneumoniae is a significant cause of nosocomial pneumonia and an alarming pathogen owing to the recent isolation of multidrug resistant strains. Understanding of immune responses orchestrating K. pneumoniae clearance...
18.
Gamradt P, Xu Y, Gratz N, Duncan K, Kobzik L, Hogler S, et al.
PLoS Pathog
. 2017 Aug;
13(8):e1006591.
PMID: 28854275
[This corrects the article DOI: 10.1371/journal.ppat.1006032.].
19.
Ebner F, Sedlyarov V, Tasciyan S, Ivin M, Kratochvill F, Gratz N, et al.
J Clin Invest
. 2017 May;
127(6):2051-2065.
PMID: 28504646
Protective responses against pathogens require a rapid mobilization of resting neutrophils and the timely removal of activated ones. Neutrophils are exceptionally short-lived leukocytes, yet it remains unclear whether the lifespan...
20.
Lang M, Berry D, Passecker K, Mesteri I, Bhuju S, Ebner F, et al.
Cancer Res
. 2017 Apr;
77(9):2424-2438.
PMID: 28428272
HuR is an RNA-binding protein implicated in immune homeostasis and various cancers, including colorectal cancer. HuR binding to AU-rich elements within the 3' untranslated region of mRNAs encoding oncogenes, growth...