Paolo La Colla
Overview
Explore the profile of Paolo La Colla including associated specialties, affiliations and a list of published articles.
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101
Citations
895
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Recent Articles
1.
Shannon A, Fattorini V, Sama B, Selisko B, Feracci M, Falcou C, et al.
Nat Commun
. 2022 Feb;
13(1):621.
PMID: 35110538
The guanosine analog AT-527 represents a promising candidate against Severe Acute Respiratory Syndrome coronavirus type 2 (SARS-CoV-2). AT-527 recently entered phase III clinical trials for the treatment of COVID-19. Once...
2.
Good S, Shannon A, Lin K, Moussa A, Julander J, La Colla P, et al.
Antimicrob Agents Chemother
. 2021 Aug;
65(11):e0098821.
PMID: 34424050
Every year, millions of people worldwide are infected with dengue virus (DENV), with a significant number developing severe life-threatening disease. There are currently no broadly indicated vaccines or therapeutics available...
3.
Good S, Westover J, Jung K, Zhou X, Moussa A, La Colla P, et al.
Antimicrob Agents Chemother
. 2021 Feb;
65(4).
PMID: 33558299
The impact of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19, is global and unprecedented. Although remdesivir has recently been approved by the FDA to treat SARS-CoV-2...
4.
Loksha Y, Pedersen E, Loddo R, La Colla P
Arch Pharm (Weinheim)
. 2016 Mar;
349(5):363-72.
PMID: 26996241
Some novel MC-1220 analogs were synthesized by condensation of 4,6-dichloro-N-methylpyrimidin-2-amine derivatives (1a,b and 15) and/or 4-chloro-6-methoxy-N,N,5-trimethylpyrimidin-2-amine (2a) with the sodium salt of 2,6-difluorophenylacetonitrile followed by treatment with aqueous sodium hydroxide...
5.
Loksha Y, Pedersen E, La Colla P, Loddo R
Org Biomol Chem
. 2015 Nov;
14(3):940-6.
PMID: 26608715
A facile and novel synthetic route to MC-1220 was achieved by condensation of 4,6-dichloro-N,N-5-trimethylpyrimidin-2-amine (1) with the sodium salt of 2,6-difluorophenylacetonitrile, followed by methylation and strong acidic hydrolysis. The prodrugs...
6.
Briguglio I, Loddo R, Laurini E, Fermeglia M, Piras S, Corona P, et al.
Eur J Med Chem
. 2015 Oct;
105:63-79.
PMID: 26479028
Linear aromatic N-tricyclic compounds with promising antiviral activity and minimal cytotoxicity were prepared and analyzed in the last years. Specifically, the pyrido[2,3-g]quinoxalinone nucleus was found endowed with high potency against...
7.
Loddo R, Novelli F, Sparatore A, Tasso B, Tonelli M, Boido V, et al.
Bioorg Med Chem
. 2015 Oct;
23(21):7024-34.
PMID: 26443549
A library of 64 benzotriazole derivatives (17 of which were [4-(benzotriazol-2-yl)phenoxy]alkanoic acids) were screened for antiviral activity against a panel of twelve DNA and RNA viruses. Twenty-six compounds (12 of...
8.
Fobofou S, Franke K, Sanna G, Porzel A, Bullita E, La Colla P, et al.
Bioorg Med Chem
. 2015 Sep;
23(19):6327-34.
PMID: 26358281
From the ethno-medicinally used leaves of Hypericum roeperianum we isolated a new tricyclic acylphloroglucinol (1), a new tetracyclic acylphloroglucinol (2), and a new prenylated bicyclic acylphloroglucinol (3) together with four...
9.
Stefanska J, Nowicka G, Struga M, Szulczyk D, Koziol A, Augustynowicz-Kopec E, et al.
Chem Pharm Bull (Tokyo)
. 2015 Mar;
63(3):225-36.
PMID: 25757494
A series of new thiourea derivatives of 1,3-thiazole have been synthesized. All obtained compounds were tested in vitro against a number of microorganisms, including Gram-positive cocci, Gram-negative rods and Candida...
10.
Grammen C, Baes M, Haenen S, Verguts J, Augustyns K, Zydowsky T, et al.
Mol Pharm
. 2014 Oct;
11(12):4405-14.
PMID: 25327902
In order to reach sufficiently high tissue concentrations and thus be effective, vaginally applied anti-HIV microbicides that are active at the level of the immune cells must permeate across the...