Paolo La Colla
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Explore the profile of Paolo La Colla including associated specialties, affiliations and a list of published articles.
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101
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895
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Recent Articles
11.
Tonelli M, Novelli F, Tasso B, Vazzana I, Sparatore A, Boido V, et al.
Bioorg Med Chem
. 2014 Aug;
22(17):4893-909.
PMID: 25082514
A library of eighty-six assorted benzimidazole derivatives was screened for antiviral activity against a panel of ten RNA and DNA viruses. Fifty-two of them displayed different levels of activity against...
12.
Loddo R, Briguglio I, Corona P, Piras S, Loriga M, Paglietti G, et al.
Eur J Med Chem
. 2014 Jul;
84:8-16.
PMID: 25014745
Continuing our program of research concerning the antiviral activity of a wide series of new angular and linear azolo bicyclic and tricyclic derivatives, now we have simplified and modified the...
13.
Loksha Y, Pedersen E, Loddo R, Sanna G, Collu G, Giliberti G, et al.
J Med Chem
. 2014 May;
57(12):5169-78.
PMID: 24805780
Novel analogues of MKC442 (6-benzyl-1-(ethoxymethyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione) were synthesized by reaction of 6-[(3,5-dimethylphenyl)fluoromethyl]-5-ethyluracil (5) with ethoxymethyl chloride and formaldehyde acetals. The Sonogashira reaction was carried out on the N1-(p-iodobenzyl)oxy]methyl derivative of compound...
14.
Bielenica A, Struga M, Miroslaw B, Koziol A, Kossakowski J, Sanna G, et al.
Acta Pol Pharm
. 2013 Oct;
70(5):809-22.
PMID: 24147359
The preparation of 16 derivatives of 3,5,8-trioxo-4-azatricyclo- [5.2.2.0(2.6)]undec-1-yl acetate and 8 derivatives of 1-isobutoxy-4-azatricyclo[5.2.2.0(2.6)]undecane-3,5,8-trione was described. Substituents to the imide N-atom were alkyl-(aryl)piperazine fragments with an alkyl linker being propyl...
15.
Spallarossa A, Rotolo C, Sissi C, Marson G, Greco M, Ranise A, et al.
Bioorg Med Chem
. 2013 Sep;
21(21):6328-36.
PMID: 24063907
Pyrimidopyrimidine derivatives 1 were prepared as rigid thioanalogues of merbarone (a catalytic topoisomerase II inhibitor) and screened as antiproliferative agents against different tumor cell lines. A number of the synthesized...
16.
Asthana S, Shukla S, Vargiu A, Ceccarelli M, Ruggerone P, Paglietti G, et al.
Biochemistry
. 2013 May;
52(21):3752-64.
PMID: 23627712
The virus-encoded RNA-dependent RNA polymerase (RdRp) has emerged as a primary target in the search for selective inhibitors of Flaviviridae. Recently, we reported on the selective inhibition, in cell-based assays,...
17.
Fetherston S, Geer L, Veazey R, Goldman L, Murphy D, Ketas T, et al.
J Antimicrob Chemother
. 2012 Oct;
68(2):394-403.
PMID: 23109186
Objectives: The non-nucleoside reverse transcriptase inhibitor MC1220 has potent in vitro activity against HIV type 1 (HIV-1). A liposome gel formulation of MC1220 has previously been reported to partially protect...
18.
Stefanska J, Szulczyk D, Koziol A, Miroslaw B, Kedzierska E, Fidecka S, et al.
Eur J Med Chem
. 2012 Aug;
55:205-13.
PMID: 22884523
A series of new thiourea derivatives of 1,2,4-triazole have been synthesized. The difference in structures of obtained compounds are directly connected with the kind of isothiocyanate (aryl/alkyl). The (1)H NMR,...
19.
Vitale G, Corona P, Loriga M, Carta A, Paglietti G, Giliberti G, et al.
Eur J Med Chem
. 2012 Apr;
53:83-97.
PMID: 22513121
Within a project aimed at discovering new Flaviviridae inhibitors, new variously substituted 2-phenylbenzimidazoles were synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against viruses representatives of the...
20.
Mandas A, Abete C, Putzu P, La Colla P, Dessi S, Pani A
Lipids Health Dis
. 2012 Mar;
11:39.
PMID: 22414021
Background: Cholesterol homeostasis dysfunction has been reported to have role in the pathogenesis of Alzheimer disease (AD). Therefore, changes in cholesterol metabolism in blood components may help to develop new...