Gregory J Kaczorowski
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Explore the profile of Gregory J Kaczorowski including associated specialties, affiliations and a list of published articles.
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68
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1067
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Recent Articles
1.
Zhu Y, de Jesus R, Tang H, Walsh S, Jiang J, Gu X, et al.
Bioorg Med Chem Lett
. 2016 Nov;
26(23):5695-5702.
PMID: 27839686
Following the discovery of small molecule acyl piperazine ROMK inhibitors, the acyl octahydropyrazino[2,1-c][1,4]oxazine series was identified. This series displays improved ROMK/hERG selectivity, and as a consequence, the resulting ROMK inhibitors...
2.
Tang H, Zhu Y, Teumelsan N, Walsh S, Shahripour A, Priest B, et al.
ACS Med Chem Lett
. 2016 Jul;
7(7):697-701.
PMID: 27437080
ROMK, the renal outer medullary potassium channel, is involved in potassium recycling at the thick ascending loop of Henle and potassium secretion at the cortical collecting duct in the kidney...
3.
Hampton C, Zhou X, Priest B, Pai L, Felix J, Thomas-Fowlkes B, et al.
J Pharmacol Exp Ther
. 2016 Jul;
359(1):194-206.
PMID: 27432892
The renal outer medullary potassium (ROMK) channel, located at the apical surface of epithelial cells in the thick ascending loop of Henle and cortical collecting duct, contributes to salt reabsorption...
4.
Garcia M, Kaczorowski G
Proc Natl Acad Sci U S A
. 2016 May;
113(20):5472-4.
PMID: 27147602
No abstract available.
5.
Walsh S, Shahripour A, Tang H, de Jesus R, Teumelsan N, Zhu Y, et al.
Bioorg Med Chem Lett
. 2016 Mar;
26(9):2339-43.
PMID: 27017115
Following the discovery of small molecule acyl piperazine ROMK inhibitors and their initial preclinical validation as a novel diuretic agent, our group set out to discover new ROMK inhibitors with...
6.
Walsh S, Shahripour A, Tang H, Teumelsan N, Frie J, Zhu Y, et al.
ACS Med Chem Lett
. 2015 Jul;
6(7):747-52.
PMID: 26191360
A new subseries of ROMK inhibitors exemplified by 28 has been developed from the initial screening hit 1. The excellent selectivity for ROMK inhibition over related ion channels and pharmacokinetic...
7.
Liu H, Zhou D, Garcia M, Kohler M, Shen X, Williams D, et al.
J Magn Reson Imaging
. 2014 Aug;
41(6):1622-8.
PMID: 25168165
Background: To characterize regional kidney sodium response by MRI following NKCC2 inhibition. Methods: Regional renal sodium signals were monitored noninvasively using (23) Na-MRI at 9.4T with a temporal resolution of...
8.
Shao P, Ye F, Chakravarty P, Herrington J, Dai G, Bugianesi R, et al.
ACS Med Chem Lett
. 2014 Jun;
4(11):1064-8.
PMID: 24900606
We report the investigation of sulfonamide-derived Cav2.2 inhibitors to address drug-metabolism liabilities with this lead class of analgesics. Modification of the benzamide substituent provided improvements in both potency and selectivity....
9.
Tang H, Walsh S, Yan Y, de Jesus R, Shahripour A, Teumelsan N, et al.
ACS Med Chem Lett
. 2014 Jun;
3(5):367-72.
PMID: 24900480
The renal outer medullary potassium channel (ROMK or Kir1.1) is a putative drug target for a novel class of diuretics that could be used for the treatment of hypertension and...
10.
Garcia M, Kaczorowski G
Curr Opin Pharmacol
. 2014 Apr;
15:1-6.
PMID: 24721647
The kidney plays a critical role in blood pressure homeostasis as a result of the integrated activity of different mechanisms that ensure proper salt and water reabsorption. Diuretics, developed more...