Osamu Takikawa
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Explore the profile of Osamu Takikawa including associated specialties, affiliations and a list of published articles.
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79
Citations
2872
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Recent Articles
1.
Yoshioka S, Ikeda T, Fukuchi S, Kawai Y, Ohta K, Murakami H, et al.
Int J Tryptophan Res
. 2022 Dec;
15:11786469221138456.
PMID: 36467776
Kynurenine (Kyn), a metabolite of tryptophan (Trp), is a key regulator of mammal immune responses such as cancer immune tolerance. Indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO) are main enzymes regulating the...
2.
Kumazawa M, Tejima M, Fukuda M, Takeda S, Suzuki K, Mizumoto Y, et al.
ACS Med Chem Lett
. 2021 Feb;
12(2):211-216.
PMID: 33603967
A structure-activity relationship study unexpectedly showed that carbonothioates and , obtained by a unique alkaline hydrolysis of 2-alkylthio-oxazolines and , respectively, are a novel scaffold for indoleamine 2,3-dioxygenase 1 (IDO1)...
3.
Duan Z, Zhang S, Liang H, Xing Z, Guo L, Shi L, et al.
Signal Transduct Target Ther
. 2020 Jun;
5(1):96.
PMID: 32532956
No abstract available.
4.
Inoue H, Matsushige T, Ichiyama T, Okuno A, Takikawa O, Tomonaga S, et al.
J Neuroimmunol
. 2019 Nov;
339:577088.
PMID: 31733567
Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disorder caused by a persistent infection with aberrant measles virus. Indoleamine-2, 3-dioxygenase (IDO) initiates the increased production of kynurenine pathway (KP) metabolites...
5.
Mikawa R, Okuno A, Yoshimi T, Watanabe A, Maruyama M, Takikawa O
Nagoya J Med Sci
. 2019 Apr;
81(1):55-64.
PMID: 30962655
The major hallmarks of Alzheimer's disease (AD) are the extracellular accumulation of pathological amyloid beta (Aβ) in the brain parenchyma and Aβ deposition in cerebral blood walls (cerebral amyloid angiopathy;...
6.
Fukuda M, Sasaki T, Hashimoto T, Miyachi H, Waki M, Asai A, et al.
Bioorg Med Chem Lett
. 2018 Jul;
28(17):2846-2849.
PMID: 30055888
Kynurenine is biosynthesised from tryptophan catalysed by indoleamine 2,3-dioxygenase (IDO). The abrogation of kynurenine production is considered a promising therapeutic target for immunological cancer treatment. In the course of our...
7.
Kayano M, Higaki S, Satoh J, Matsumoto K, Matsubara E, Takikawa O, et al.
Biomark Res
. 2016 Dec;
4():22.
PMID: 27999671
Background: Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia including Alzheimer's disease. Early detection of dementia, and MCI, is a crucial issue in terms of...
8.
Coluccia A, Passacantilli S, Famiglini V, Sabatino M, Patsilinakos A, Ragno R, et al.
J Med Chem
. 2016 Oct;
59(21):9760-9773.
PMID: 27690429
Indoleamine 2,3-dioxygenase 1 (IDO1) is an attractive target for anticancer therapy. Herein, we report a virtual screening study which led to the identification of compound 5 as a new IDO1...
9.
Wang D, Saga Y, Sato N, Nakamura T, Takikawa O, Mizukami H, et al.
Int J Oncol
. 2016 Apr;
48(6):2303-9.
PMID: 27082119
Indoleamine-2,3-dioxygenase (IDO) is an immunosuppressive enzyme involved in tumor malignancy. However, the regulatory mechanism underlying its involvement remains largely uncharacterized. The present study aimed to investigate the hypothesis that NK4,...
10.
Yoshio S, Sugiyama M, Shoji H, Mano Y, Mita E, Okamoto T, et al.
Hepatology
. 2015 Oct;
63(1):83-94.
PMID: 26458241
Unlabelled: Indoleamine-2, 3-dioxygenase (IDO), an interferon-γ-inducible enzyme catalyzing tryptophan into kynurenine, exerts dual functions in infectious diseases, acting as a suppressor of intracellular pathogens and as an immune regulator. We...