Mikhail F Gordeev
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Explore the profile of Mikhail F Gordeev including associated specialties, affiliations and a list of published articles.
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16
Citations
129
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Recent Articles
1.
Wang W, Li Z, Gordeev M, Yuan H
J Appl Toxicol
. 2024 Jan;
44(5):770-783.
PMID: 38237604
Contezolid acefosamil (CZA) is an intravenous prodrug of oxazolidinone antibiotic contezolid (CZD). It is being developed to treat infections due to Gram-positive bacteria including multidrug-resistant pathogens, while addressing myelosuppression and...
2.
Liu J, Wang W, Wang C, Zhang L, Zhang X, Liu S, et al.
ACS Med Chem Lett
. 2022 Jul;
13(7):1030-1035.
PMID: 35859881
New oral antibiotic contezolid (CZD) is effective against Gram-positive infections but unsuitable for intravenous (IV) administration due to its modest solubility. To address the medical need for an IV form...
3.
Wu X, Meng J, Yuan H, Zhong D, Yu J, Cao G, et al.
Antimicrob Agents Chemother
. 2021 Aug;
65(11):e0040921.
PMID: 34398672
Contezolid (MRX-I), a novel oxazolidinone antibiotic, was recently approved for the treatment of serious Gram-positive infections. The pharmacokinetics and disposition of [C]contezolid were investigated in a single-dose human mass balance...
4.
Wang W, Voss K, Liu J, Gordeev M
Chem Res Toxicol
. 2021 Apr;
34(5):1348-1354.
PMID: 33913699
Linezolid, the principal oxazolidinone antibiotic for therapy of Gram-positive infections, is limited by its myelosuppression and monoamine oxidase (MAO) inhibition, with the latter manifested as serotonergic neurotoxicity. The oral oxazolidinone...
5.
Huang Y, Xu Y, Liu S, Wang H, Xu X, Guo Q, et al.
Int J Antimicrob Agents
. 2014 Apr;
43(5):418-22.
PMID: 24721233
MRX-I is a new oxazolidinone antimicrobial under development. In this study, the potential for development of resistance to MRX-I in Staphylococcus aureus was investigated and key mutations were characterised. Determination...
6.
Gordeev M, Yuan Z
J Med Chem
. 2014 Apr;
57(11):4487-97.
PMID: 24694071
Oxazolidinones comprise an important class of antibacterial protein synthesis inhibitors. Myelosuppression and monoamine oxidase inhibition (MAOI) are key independent causes for limiting adverse effects in therapy with the sole approved...
7.
ODowd H, Lewis J, Trias J, Asano R, Blais J, Lopez S, et al.
Bioorg Med Chem Lett
. 2008 Mar;
18(8):2645-8.
PMID: 18359228
The synthesis and evaluation of novel azetidine lincosamides 1 are described. Eleven new (3-trans-alkyl)azetidine-2-carboxylic acids were synthesized via alkylation of N-TBS-4-oxo-azetidine-2-carboxylic acid and subsequent elaboration then coupled to 7-chloro-1-methylthio-lincosamine. The...
8.
Renslo A, Atuegbu A, Herradura P, Jaishankar P, Ji M, Leach K, et al.
Bioorg Med Chem Lett
. 2007 Aug;
17(18):5036-40.
PMID: 17681758
Oxazolidinone analogs bearing substituted piperidine or azetidine C-rings are described. Analogs with a methyl group at the 3-position of the azetidine ring or the 4-position of the piperidine ring exhibited...
9.
Renslo A, Luehr G, Lam S, Westlund N, Gomez M, Hackbarth C, et al.
Bioorg Med Chem Lett
. 2006 Apr;
16(13):3475-8.
PMID: 16644216
A new series of antimicrobial oxazolidinones bearing unsaturated heterocyclic C-rings is described. Dihydrothiopyran derivatives were prepared from the saturated tetrahydrothiopyran sulfoxides via a Pummerer-rearrangement/elimination sequence. Two new synthetic approaches to...
10.
Renslo A, Luehr G, Gordeev M
Bioorg Med Chem
. 2006 Mar;
14(12):4227-40.
PMID: 16527486
The oxazolidinones are a promising new class of synthetic antibacterial agents. Here, we review recent efforts directed at the discovery of new antibacterial compounds of this class. New structures and...