Dinesh V Patel
Overview
Explore the profile of Dinesh V Patel including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
15
Citations
201
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ranganath S, Bhandari A, Avitahl-Curtis N, McMahon J, Wachtel D, Zhang J, et al.
PLoS One
. 2015 Nov;
10(11):e0141330.
PMID: 26555695
Interleukin-6 (IL-6) is an important member of the cytokine superfamily, exerting pleiotropic actions on many physiological processes. Over-production of IL-6 is a hallmark of immune-mediated inflammatory diseases such as Castleman's...
2.
Chen D, Whitcomb R, MacIntyre E, Tran V, Do Z, Sabry J, et al.
J Clin Pharmacol
. 2011 Mar;
52(3):319-28.
PMID: 21422238
AR9281, a potent and selective inhibitor of soluble epoxide hydrolase (s-EH), is in clinical development targeting hypertension and type 2 diabetes. The safety, pharmacokinetics, and pharmacodynamics of AR9281 were evaluated...
3.
Anandan S, Webb H, Chen D, Wang Y, Aavula B, Cases S, et al.
Bioorg Med Chem Lett
. 2011 Jan;
21(3):983-8.
PMID: 21211973
1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea 14a (AR9281), a potent and selective soluble epoxide hydrolase inhibitor, was recently tested in a phase 2a clinical setting for its effectiveness in reducing blood pressure and improving insulin...
4.
Anandan S, Do Z, Webb H, Patel D, Gless R
Bioorg Med Chem Lett
. 2009 Jan;
19(4):1066-70.
PMID: 19168352
Inhibition of soluble epoxide hydrolase has been proposed as a promising new pharmaceutical target for diseases involving hypertension and vascular inflammation. The most potent sEH inhibitors reported to date contain...
5.
Anandan S, Ward J, Brokx R, Denny T, Bray M, Patel D, et al.
Bioorg Med Chem Lett
. 2007 Sep;
17(21):5995-9.
PMID: 17827005
We have designed and synthesized a series of structurally novel hydroxamic acid-based histone deacetylase (HDAC) inhibitors characterized by a zinc chelating head group attached directly to a thiazole ring. The...
6.
Renslo A, Luehr G, Lam S, Westlund N, Gomez M, Hackbarth C, et al.
Bioorg Med Chem Lett
. 2006 Apr;
16(13):3475-8.
PMID: 16644216
A new series of antimicrobial oxazolidinones bearing unsaturated heterocyclic C-rings is described. Dihydrothiopyran derivatives were prepared from the saturated tetrahydrothiopyran sulfoxides via a Pummerer-rearrangement/elimination sequence. Two new synthetic approaches to...
7.
Renslo A, Jaishankar P, Venkatachalam R, Hackbarth C, Lopez S, Patel D, et al.
J Med Chem
. 2005 Jul;
48(15):5009-24.
PMID: 16033280
The oxazolidinones are a new class of synthetic antibacterials effective against a broad range of pathogenic Gram-positive bacteria, including multi-drug-resistant strains. Linezolid is the first drug from this class to...
8.
Anandan S, Ward J, Brokx R, Bray M, Patel D, Xiao X
Bioorg Med Chem Lett
. 2005 Apr;
15(8):1969-72.
PMID: 15808449
Inhibitors of histone deacetylases (HDAC) are emerging as a promising class of anti-cancer agents. A mercaptoamide functionality was designed as a bidentate zinc chelator and incorporated into the hydroxamic acid...
9.
Raju B, Anandan S, Gu S, Herradura P, ODowd H, Kim B, et al.
Bioorg Med Chem Lett
. 2004 May;
14(12):3103-7.
PMID: 15149653
Deoxynegamycin (1b) is a protein synthesis inhibitor with activity against Gram-negative (GN) bacteria. A series of conformationally restricted analogs were synthesized to probe its bioactive conformation. Indeed, some of the...
10.
Gordeev M, Hackbarth C, Barbachyn M, Banitt L, Gage J, Luehr G, et al.
Bioorg Med Chem Lett
. 2003 Nov;
13(23):4213-6.
PMID: 14623004
Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2, 5, and 6 display an improved potency versus linezolid against gram-positive and fastidious gram-negative...