Adam R Renslo
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Explore the profile of Adam R Renslo including associated specialties, affiliations and a list of published articles.
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123
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3067
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Recent Articles
1.
Klope M, Tapia Cardona J, Chen J, Gonciarz R, Cheng K, Jaishankar P, et al.
ACS Med Chem Lett
. 2024 Oct;
15(10):1764-1770.
PMID: 39411530
The recent withdrawal of artefenomel from clinical development leaves no endoperoxide-class agents in the antimalarial pipeline. Synthetic endoperoxides with a desymmetrized structure have demonstrated promising physiochemical and properties. Here we...
2.
Flowers J, Echols N, Correy G, Jaishankar P, Togo T, Renslo A, et al.
bioRxiv
. 2024 Oct;
PMID: 39386683
Small molecule ligands exhibit a diverse range of conformations in solution. Upon binding to a target protein, this conformational diversity is generally reduced. However, ligands can retain some degree of...
3.
Correy G, Rachman M, Togo T, Gahbauer S, Doruk Y, Stevens M, et al.
bioRxiv
. 2024 Sep;
PMID: 39253507
The macrodomain contained in the SARS-CoV-2 non-structural protein 3 (NSP3) is required for viral pathogenesis and lethality. Inhibitors that block the macrodomain could be a new therapeutic strategy for viral...
4.
Suryawanshi R, Jaishankar P, Correy G, Rachman M, OLeary P, Taha T, et al.
bioRxiv
. 2024 Aug;
PMID: 39149230
SARS-CoV-2 continues to pose a threat to public health. Current therapeutics remain limited to direct acting antivirals that lack distinct mechanisms of action and are already showing signs of viral...
5.
Deal P, Lee H, Mondal A, Lolicato M, Furtado de Mendonca P, Black H, et al.
Cell Chem Biol
. 2024 Jul;
31(7):1305-1323.e9.
PMID: 39029456
K potassium channels regulate excitability by affecting cellular resting membrane potential in the brain, cardiovascular system, immune cells, and sensory organs. Despite their important roles in anesthesia, arrhythmia, pain, hypertension,...
6.
Pezacki A, Gonciarz R, Okamura T, Matier C, Torrente L, Cheng K, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(28):e2401579121.
PMID: 38968123
Iron is an essential element for life owing to its ability to participate in a diverse array of oxidation-reduction reactions. However, misregulation of iron-dependent redox cycling can also produce oxidative...
7.
Deal P, Lee H, Mondal A, Lolicato M, Furtado de Mendonca P, Black H, et al.
bioRxiv
. 2023 Oct;
PMID: 37905049
K potassium channels regulate excitability by affecting cellular resting membrane potential in the brain, cardiovascular system, immune cells, and sensory organs. Despite their important roles in anesthesia, arrhythmia, pain, hypertension,...
8.
Gonciarz R, Jiang H, Tram L, Hugelshofer C, Ekpenyong O, Knemeyer I, et al.
Cell Chem Biol
. 2023 Oct;
30(11):1468-1477.e6.
PMID: 37820725
Dysregulated iron homeostasis underlies diverse pathologies, from ischemia-reperfusion injury to epithelial-mesenchymal transition and drug-tolerant "persister" cancer cell states. Here, we introduce ferrous iron-activatable luciferin-1 (FeAL-1), a small-molecule probe for bioluminescent...
9.
Foss C, Renslo A
J Infect Dis
. 2023 Oct;
228(Suppl 4):S302-S310.
PMID: 37788497
Recently developed molecular imaging approaches can be used to visualize specific host responses and pathology in a quest to image infections where few microbe-specific tracers have been developed and in...
10.
Konstantinidou M, Visser E, Vandenboorn E, Chen S, Jaishankar P, Overmans M, et al.
J Am Chem Soc
. 2023 Sep;
145(37):20328-20343.
PMID: 37676236
The stabilization of protein-protein interactions (PPIs) has emerged as a promising strategy in chemical biology and drug discovery. The identification of suitable starting points for stabilizing native PPIs and their...