Michele A Cleary
Overview
Explore the profile of Michele A Cleary including associated specialties, affiliations and a list of published articles.
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37
Citations
4248
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Recent Articles
1.
McLaren D, Previs S, Phair R, Stout S, Xie D, Chen Y, et al.
J Lipid Res
. 2015 Dec;
57(3):398-409.
PMID: 26658238
Studies in lipoprotein kinetics almost exclusively rely on steady-state approaches to modeling. Herein, we have used a non-steady-state experimental design to examine the role of cholesteryl ester transfer protein (CETP)...
2.
Previs S, Herath K, Castro-Perez J, Mahsut A, Zhou H, McLaren D, et al.
Methods Enzymol
. 2015 Sep;
561:331-58.
PMID: 26358910
Stable isotope tracers are widely used to quantify metabolic rates, and yet a limited number of studies have considered the impact of analytical error on estimates of flux. For example,...
3.
Paulson K, Tegeder A, Willmes C, Iyer J, Afanasiev O, Schrama D, et al.
Cancer Immunol Res
. 2014 Aug;
2(11):1071-9.
PMID: 25116754
Merkel cell carcinoma (MCC) is an aggressive, polyomavirus-associated skin cancer. Robust cellular immune responses are associated with excellent outcomes in patients with MCC, but these responses are typically absent. We...
4.
Roddy T, McLaren D, Chen Y, Xie D, Dunn K, Kulick A, et al.
Eur J Pharmacol
. 2014 Apr;
740:410-6.
PMID: 24769414
Inhibition of cholesteryl ester transfer protein (CETP) has been vigorously pursued as a potential therapy to treat patients who are at an elevated risk for coronary artery disease. Anacetrapib, a...
5.
Conrad W, Major M, Cleary M, Ferrer M, Roberts B, Marine S, et al.
F1000Res
. 2014 Feb;
2:134.
PMID: 24358901
The inability of targeted BRAF inhibitors to produce long-lasting improvement in the clinical outcome of melanoma highlights a need to identify additional approaches to inhibit melanoma growth. Recent studies have...
6.
Herath K, Zhong W, Yang J, Mahsut A, Rohm R, Shah V, et al.
Rapid Commun Mass Spectrom
. 2013 Dec;
28(3):239-44.
PMID: 24375874
Rationale: The ability to measure low levels of (2)H-labeling is important in studies of metabolic flux, e.g. one can estimate lipid synthesis by administering (2)H2O and then measuring the incorporation...
7.
Previs S, McLaren D, Wang S, Stout S, Zhou H, Herath K, et al.
Biochim Biophys Acta
. 2013 May;
1842(3):402-13.
PMID: 23707557
Our ability to understand the pathogenesis of problems surrounding lipid accretion requires attention towards quantifying lipid kinetics. In addition, studies of metabolic flux should also help unravel mechanisms that lead...
8.
McLaren D, Cardasis H, Stout S, Wang S, Mendoza V, Castro-Perez J, et al.
Anal Chem
. 2013 May;
85(13):6287-94.
PMID: 23668715
We have previously reported on a liquid chromatography-mass spectrometry method to determine the disposition of [(13)C18]-oleic acid following intravenous and oral administration in vivo. This approach has enabled us to...
9.
Dey J, Ditzler S, Knoblaugh S, Hatton B, Schelter J, Cleary M, et al.
Mol Cell Biol
. 2012 Aug;
32(20):4104-15.
PMID: 22869526
Deregulated developmental processes in the cerebellum cause medulloblastoma, the most common pediatric brain malignancy. About 25 to 30% of cases are caused by mutations increasing the activity of the Sonic...
10.
Stec E, Locco L, Szymanski S, Bartz S, Toniatti C, Needham R, et al.
J Biomol Screen
. 2012 Jul;
17(10):1316-28.
PMID: 22786893
Gene silencing by RNA interference has become a powerful tool to help identify genes that regulate biological processes. However, the complexity of the biology probed and the incomplete validation of...