Michele A Cleary
Overview
Explore the profile of Michele A Cleary including associated specialties, affiliations and a list of published articles.
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37
Citations
4248
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Recent Articles
11.
Toyoshima M, Howie H, Imakura M, Walsh R, Annis J, Chang A, et al.
Proc Natl Acad Sci U S A
. 2012 May;
109(24):9545-50.
PMID: 22623531
MYC oncogene family members are broadly implicated in human cancers, yet are considered "undruggable" as they encode transcription factors. MYC also carries out essential functions in proliferative tissues, suggesting that...
12.
Warrener P, Kim S, Williams S, Biery M, Gordon M, Toniatti C, et al.
Apoptosis
. 2012 Mar;
17(7):691-701.
PMID: 22392482
Tumor suppressor genes BRCA1 and BRCA2 function in a complex gene network that regulates homologous recombination and DNA double-strand break repair. Disruption of the BRCA-network through gene mutation, deletion, or...
13.
Sundaram P, Hultine S, Smith L, Dews M, Fox J, Biyashev D, et al.
Cancer Res
. 2011 Oct;
71(24):7490-501.
PMID: 22028325
Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis encoded by the THBS1 gene, whose promoter is activated by p53. In advanced colorectal cancers (CRC), its expression is sustained or even...
14.
Ivanovska I, Zhang C, Liu A, Wong K, Lee N, Lewis P, et al.
PLoS One
. 2011 Sep;
6(9):e24582.
PMID: 21949730
Biomarkers derived from gene expression profiling data may have a high false-positive rate and must be rigorously validated using independent clinical data sets, which are not always available. Although animal...
15.
Luk J, Burchard J, Zhang C, Liu A, Wong K, Shek F, et al.
J Biol Chem
. 2011 Jul;
286(35):30706-30713.
PMID: 21737452
Hepatocellular carcinoma (HCC) is a heterogeneous and highly aggressive malignancy, for which there are no effective cures. Identification of a malignant stemlike subtype of HCC may offer patients with a...
16.
Mathieu J, Zhang Z, Zhou W, Wang A, Heddleston J, Pinna C, et al.
Cancer Res
. 2011 Jun;
71(13):4640-52.
PMID: 21712410
Low oxygen levels have been shown to promote self-renewal in many stem cells. In tumors, hypoxia is associated with aggressive disease course and poor clinical outcomes. Furthermore, many aggressive tumors...
17.
Paulson K, Iyer J, Tegeder A, Thibodeau R, Schelter J, Koba S, et al.
J Clin Oncol
. 2011 Mar;
29(12):1539-46.
PMID: 21422430
Purpose: Merkel cell carcinoma (MCC) is a polyomavirus-associated skin cancer that is frequently lethal and lacks established prognostic biomarkers. This study sought to identify biomarkers that improve prognostic accuracy and...
18.
Dews M, Fox J, Hultine S, Sundaram P, Wang W, Liu Y, et al.
Cancer Res
. 2010 Oct;
70(20):8233-46.
PMID: 20940405
c-Myc stimulates angiogenesis in tumors through mechanisms that remain incompletely understood. Recent work indicates that c-Myc upregulates the miR-17∼92 microRNA cluster and downregulates the angiogenesis inhibitor thrombospondin-1, along with other...
19.
Klinghoffer R, Magnus J, Schelter J, Mehaffey M, Coleman C, Cleary M
RNA
. 2010 Mar;
16(5):879-84.
PMID: 20348445
Along with silencing intended target genes, transfected siRNAs regulate numerous unintended transcripts through a mechanism in which the equivalent of a microRNA-like seed region in the siRNA recognizes complementary sequences...
20.
Stadler B, Ivanovska I, Mehta K, Song S, Nelson A, Tan Y, et al.
Stem Cells Dev
. 2010 Feb;
19(7):935-50.
PMID: 20128659
Studies of embryonic stem cells (ESCs) reveal that these cell lines can be derived from differing stages of embryonic development. We analyzed common changes in the expression of microRNAs (miRNAs)...