Peter S Linsley
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Explore the profile of Peter S Linsley including associated specialties, affiliations and a list of published articles.
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100
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18546
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Recent Articles
1.
Higdon L, Cooney L, Serti E, Suwannasaen D, Muir V, Wiedeman A, et al.
J Immunol
. 2025 Mar;
214(1):12-22.
PMID: 40073269
The CD2-depleting drug alefacept (LFA3-Ig) preserved beta cell function in new-onset type 1 diabetes (T1D) patients. The most promising biomarkers of response were late expansion of exhausted CD8 T cells...
2.
Lledo-Delgado A, Preston-Hurlburt P, Currie S, Clark P, Linsley P, Long S, et al.
J Clin Invest
. 2024 Aug;
134(18).
PMID: 39137044
BACKGROUNDTeplizumab, a non-FcR-binding anti-CD3 mAb, is approved to delay progression of type 1 diabetes (T1D) in at-risk patients. Previous investigations described the immediate effects of the 14-day treatment, but longer-term...
3.
Witkop E, Diggins K, Wiedeman A, Serti E, Nepom G, Gersuk V, et al.
Commun Biol
. 2024 Jun;
7(1):773.
PMID: 38937521
Distinct Natural Killer (NK)-like CD57 and PD-1 CD8 exhausted-like T cell populations (Tex) have both been linked to beneficial immunotherapy response in autoimmune type 1 diabetes (T1D) patients. The origins...
4.
Linsley P, Nakayama M, Balmas E, Chen J, Barahmand-Pour-Whitman F, Bansal S, et al.
Nat Commun
. 2024 Jun;
15(1):4971.
PMID: 38871688
Human type 1 diabetes (T1D) is caused by autoimmune attack on the insulin-producing pancreatic beta cells by islet antigen-reactive T cells. How human islet antigen-reactive (IAR) CD4+ memory T cells...
5.
Long S, Linsley P
Cold Spring Harb Perspect Med
. 2024 May;
14(7).
PMID: 38772709
Biomarkers are critical to the staging and diagnosis of type 1 diabetes (T1D). Functional biomarkers offer insights into T1D immunopathogenesis and are often revealed using "omics" approaches that integrate multiple...
6.
Long S, Muir V, Jones B, Wall V, Ylescupidez A, Hocking A, et al.
Front Immunol
. 2024 Apr;
15:1383110.
PMID: 38650930
Exhausted CD8 T cells (T) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGITKLRG1 T with teplizumab therapy in...
7.
Balmas E, Chen J, Hu A, DeBerg H, Rosasco M, Gersuk V, et al.
JCI Insight
. 2023 Sep;
8(21.
PMID: 37751304
Variation in the preservation of β cell function in clinical trials in type 1 diabetes (T1D) has emphasized the need to define biomarkers to predict treatment response. The T1DAL trial...
8.
Jacobsen L, Diggins K, Blanchfield L, McNichols J, Perry D, Brant J, et al.
JCI Insight
. 2023 Jul;
8(16).
PMID: 37432736
BACKGROUNDLow-dose anti-thymocyte globulin (ATG) transiently preserves C-peptide and lowers HbA1c in individuals with recent-onset type 1 diabetes (T1D); however, the mechanisms of action and features of the response remain unclear....
9.
Anderson W, Barahmand-Pour-Whitman F, Linsley P, Cerosaletti K, Buckner J, Rawlings D
Elife
. 2023 Mar;
12.
PMID: 36961507
A genetic variant in the gene (R620W, rs2476601) is strongly associated with increased risk for multiple autoimmune diseases and linked to altered TCR regulation and T cell activation. Here, we...
10.
Chiu H, Linsley P, Ziegler S
J Immunol
. 2023 Mar;
210(7):888-894.
PMID: 36947816
The thymus is an intricate organ consisting of a diverse population of thymic epithelial cells (TECs). Cortical and medullary TECs and their subpopulations have distinct roles in coordinating the development...