Michael Weinfeld
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Explore the profile of Michael Weinfeld including associated specialties, affiliations and a list of published articles.
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Articles
114
Citations
2848
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Recent Articles
21.
El Gendy M, Hassanein H, Saleh F, Karimi-Busheri F, Fanta M, Yang X, et al.
Life Sci
. 2022 Feb;
295:120380.
PMID: 35143825
Aims: the main purpose of this study was to identify new selective antitumor agents. Main Methods: several hydrazonoyl chlorides (HCs) were synthesized and human tumor cell line viability was determined...
22.
Sadat S, Wuest M, Paiva I, Munira S, Sarrami N, Sanaee F, et al.
Front Oncol
. 2022 Jan;
11:772920.
PMID: 35004293
Inhibition of the DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) increases the sensitivity of cancer cells to DNA damage by ionizing radiation (IR). We have developed a novel inhibitor of PNKP,...
23.
El Gendy M, Weinfeld M, Abdoon A
Anticancer Agents Med Chem
. 2021 Jul;
22(5):991-998.
PMID: 34315395
Background: Gold nanorods (GNRs) are very promising agents with multiple applications in medicine and biology. However, the cytotoxic effects of GNRs have not been fully explored. Objective: Therefore, the main...
24.
Shin W, Alpaugh W, Hallihan L, Sinha S, Crowther E, Martin G, et al.
Life Sci Alliance
. 2021 Jul;
4(9).
PMID: 34226276
DNA repair proteins are critical to the maintenance of genomic integrity. Specific types of genotoxic factors, including reactive oxygen species generated during normal cellular metabolism or as a result of...
25.
Sadat S, Paiva I, Shire Z, Sanaee F, Morgan T, Paladino M, et al.
J Control Release
. 2021 May;
334:335-352.
PMID: 33933518
Phosphatase and TENsin homolog deleted on chromosome 10 (PTEN) is a major tumor-suppressor protein that is lost in up to 75% of aggressive colorectal cancers (CRC). The co-depletion of PTEN...
26.
Rashed F, Stoica A, Macdonald D, El-Saidi H, Ricardo C, Bhatt B, et al.
Redox Biol
. 2021 Apr;
44:101986.
PMID: 33910780
No abstract available.
27.
Rashed F, Stoica A, Macdonald D, El-Saidi H, Ricardo C, Bhatt B, et al.
Redox Biol
. 2021 Feb;
41:101905.
PMID: 33640700
Tumour hypoxia negatively impacts therapy outcomes and continues to be a major unsolved clinical problem. Nitroimidazoles are hypoxia selective compounds that become entrapped in hypoxic cells by forming drug-protein adducts....
28.
Ciniero G, Elmenoufy A, Gentile F, Weinfeld M, Deriu M, West F, et al.
Cancer Chemother Pharmacol
. 2021 Jan;
87(2):259-267.
PMID: 33399940
Purpose: The ERCC1-XPF 5'-3' DNA endonuclease complex is involved in the nucleotide excision repair pathway and in the DNA inter-strand crosslink repair pathway, two key mechanisms modulating the activity of...
29.
Sadat S, Vakili M, Paiva I, Weinfeld M, Lavasanifar A
Pharmaceutics
. 2020 Nov;
12(11).
PMID: 33138058
The clinical use of 7-ethyl-10-hydroxy-camptothecin (SN-38), which is the active metabolite of irinotecan, has been hampered because of its practical water-insolubility. In this study, we successfully synthesized two self-associating SN-38-polymer...
30.
Elmenoufy A, Gentile F, Jay D, Karimi-Busheri F, Yang X, Soueidan O, et al.
Eur J Med Chem
. 2020 Aug;
204:112658.
PMID: 32738410
The structure-specific ERCC1-XPF endonuclease is essential for repairing bulky DNA lesions and helix distortions induced by UV radiation, which forms cyclobutane pyrimidine dimers (CPDs), or chemicals that crosslink DNA strands...