Michael Weinfeld
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Explore the profile of Michael Weinfeld including associated specialties, affiliations and a list of published articles.
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114
Citations
2848
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Recent Articles
11.
Tao J, Zhang H, Weinfeld M, Le X
Anal Chem
. 2023 Sep;
95(40):14990-14997.
PMID: 37725609
DNAzyme walker technology is a compelling option for bioanalytical and drug delivery applications. While nucleic acid and protein targets have been used to activate DNAzyme walkers, investigations into enzyme-triggered DNAzyme...
12.
Diaz-Dussan D, Peng Y, Rashed F, Macdonald D, Weinfeld M, Kumar P, et al.
Mol Pharm
. 2023 May;
20(6):3100-3114.
PMID: 37148327
Solid tumors are often poorly vascularized, which impairs oxygen supply and drug delivery to the cells. This often leads to genetic and translational adaptations that promote tumor progression, invasion, metastasis,...
13.
Rashed F, Kate W, Fanta M, Wiebe L, Kumar P, Weinfeld M
Antioxidants (Basel)
. 2023 Feb;
12(2).
PMID: 36829948
Cellular adaptations to hypoxia promote resistance to ionizing radiation (IR). This presents a challenge for treatment of head and neck cancer (HNC) that relies heavily on radiotherapy. Standard radiosensitizers often...
14.
Jackson N, Alhussan A, Bromma K, Jay D, Donnelly J, West F, et al.
Pharmaceutics
. 2022 Dec;
14(12).
PMID: 36559288
Radiation therapy (RT) is frequently used to locally treat tumors. One of the major issues in RT is normal tissue toxicity; thus, it is necessary to limit dose escalation for...
15.
Turchi J, Pawelczak K, Weinfeld M, McHugh P
Front Oncol
. 2022 Oct;
12:1023500.
PMID: 36237323
No abstract available.
16.
Rashed F, Diaz-Dussan D, Mashayekhi F, Macdonald D, Nation P, Yang X, et al.
Redox Biol
. 2022 Apr;
52:102300.
PMID: 35430547
Solid tumours are often poorly oxygenated, which confers resistance to standard treatment modalities. Targeting hypoxic tumours requires compounds, such as nitroimidazoles (NIs), equipped with the ability to reach and become...
17.
Rychlowska M, Agyapong A, Weinfeld M, Schang L
J Virol
. 2022 Apr;
96(9):e0033322.
PMID: 35412344
Vertical transmission of Zika virus (ZIKV) leads with high frequency to congenital ZIKV syndrome (CZS), whose worst outcome is microcephaly. However, the mechanisms of congenital ZIKV neurodevelopmental pathologies, including direct...
18.
Weilbeer C, Jay D, Donnelly J, Gentile F, Karimi-Busheri F, Yang X, et al.
Front Oncol
. 2022 Apr;
12:819172.
PMID: 35372043
Inhibition of DNA repair enzymes is an attractive target for increasing the efficacy of DNA damaging chemotherapies. The ERCC1-XPF heterodimer is a key endonuclease in numerous single and double strand...
19.
Jiang B, Murray C, Cole B, Glover J, Chan G, Deschenes J, et al.
Sci Rep
. 2022 Mar;
12(1):5386.
PMID: 35354845
Polynucleotide Kinase-Phosphatase (PNKP) is a bifunctional enzyme that possesses both DNA 3'-phosphatase and DNA 5'-kinase activities, which are required for processing termini of single- and double-strand breaks generated by reactive...
20.
Paiva I, Vakili M, Soleimani A, Tabatabaei Dakhili S, Munira S, Paladino M, et al.
Mol Pharm
. 2022 Mar;
19(6):1825-1838.
PMID: 35271294
The disruption of polynucleotide kinase/phosphatase (PNKP) in colorectal cancer (CRC) cells deficient in phosphatase and tensin homolog (PTEN) is expected to lead to the loss of cell viability by a...