Ahmed H Elmenoufy
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Explore the profile of Ahmed H Elmenoufy including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
170
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Recent Articles
1.
Mehinrad P, Abdelfattah A, Sadat S, Shafaati T, Elmenoufy A, Jay D, et al.
Drug Deliv Transl Res
. 2025 Jan;
PMID: 39878858
In this study, a novel inhibitor of ERCC1/XPF heterodimerization, A4, was used as an inhibitor of repair for DNA damage by platinum-based chemotherapeutics. Nano-formulations of A4 were developed, using self-assembly...
2.
Ciniero G, Pedro T, Dumontet C, Elmenoufy A, West F, Weinfeld M, et al.
Fundam Clin Pharmacol
. 2024 Nov;
39(1):e13043.
PMID: 39520092
Background: DNA repair plays a major role in maintaining genomic stability, thus limiting the transformation of normal cells into cancer cells. However, in cancer patients treated with DNA-targeting drugs, DNA...
3.
Weilbeer C, Jay D, Donnelly J, Gentile F, Karimi-Busheri F, Yang X, et al.
Front Oncol
. 2022 Apr;
12:819172.
PMID: 35372043
Inhibition of DNA repair enzymes is an attractive target for increasing the efficacy of DNA damaging chemotherapies. The ERCC1-XPF heterodimer is a key endonuclease in numerous single and double strand...
4.
Ciniero G, Elmenoufy A, Gentile F, Weinfeld M, Deriu M, West F, et al.
Cancer Chemother Pharmacol
. 2021 Jan;
87(2):259-267.
PMID: 33399940
Purpose: The ERCC1-XPF 5'-3' DNA endonuclease complex is involved in the nucleotide excision repair pathway and in the DNA inter-strand crosslink repair pathway, two key mechanisms modulating the activity of...
5.
Elmenoufy A, Gentile F, Jay D, Karimi-Busheri F, Yang X, Soueidan O, et al.
Eur J Med Chem
. 2020 Aug;
204:112658.
PMID: 32738410
The structure-specific ERCC1-XPF endonuclease is essential for repairing bulky DNA lesions and helix distortions induced by UV radiation, which forms cyclobutane pyrimidine dimers (CPDs), or chemicals that crosslink DNA strands...
6.
Computer-aided drug design of small molecule inhibitors of the ERCC1-XPF protein-protein interaction
Gentile F, Elmenoufy A, Ciniero G, Jay D, Karimi-Busheri F, Barakat K, et al.
Chem Biol Drug Des
. 2020 Jan;
95(4):460-471.
PMID: 31891209
The heterodimer of DNA excision repair protein ERCC-1 and DNA repair endonuclease XPF (ERCC1-XPF) is a 5'-3' structure-specific endonuclease essential for the nucleotide excision repair (NER) pathway, and it is...
7.
Elmenoufy A, Gentile F, Jay D, Karimi-Busheri F, Yang X, Soueidan O, et al.
J Med Chem
. 2019 Aug;
62(17):7684-7696.
PMID: 31369707
The ERCC1-XPF heterodimer is a 5'-3' structure-specific endonuclease, which plays an essential role in several DNA repair pathways in mammalian cells. ERCC1-XPF is primarily involved in the repair of chemically...
8.
Hu J, Tang Y, Elmenoufy A, Xu H, Cheng Z, Yang X
Small
. 2015 Sep;
11(44):5860-87.
PMID: 26398119
Photodynamic therapy (PDT), as an emerging clinically approved modality, has been used for treatment of various cancer diseases. Conventional PDT strategies are mainly focused on superficial lesions because the wavelength...
9.
Elmenoufy A, Tang Y, Hu J, Xu H, Yang X
Chem Commun (Camb)
. 2015 Jul;
51(61):12247-50.
PMID: 26136105
Multifunctional LaF3:Tb scintillating nanoparticles (ScNPs) coated with homogenous layers of silica and subsequently tethered with RB covalently were elaborated. The nanoconjugates with a high colloidal stability and biocompatibility could generate...
10.
Tang Y, Hu J, Elmenoufy A, Yang X
ACS Appl Mater Interfaces
. 2015 May;
7(22):12261-9.
PMID: 25974980
Photodynamic therapy (PDT) for deep-seated tumor is largely impeded by the limited penetration depth of excitation light in tissue. X-ray is considered as an ideal energy source to activate photosensitizers...