Michael W Crowder
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Explore the profile of Michael W Crowder including associated specialties, affiliations and a list of published articles.
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96
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1569
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Recent Articles
1.
Cheng Z, Aitha M, Thomas C, Sturgill A, Fairweather M, Hu A, et al.
J Chem Inf Model
. 2024 May;
64(10):3977-3991.
PMID: 38727192
The worldwide spread of the metallo-β-lactamases (MBL), especially New Delhi metallo-β-lactamase-1 (NDM-1), is threatening the efficacy of β-lactams, which are the most potent and prescribed class of antibiotics in the...
2.
Xu R, Zhang H, Crowder M, Zhu J
Brief Bioinform
. 2024 Feb;
25(2).
PMID: 38385875
Metabolomics and foodomics shed light on the molecular processes within living organisms and the complex food composition by leveraging sophisticated analytical techniques to systematically analyze the vast array of molecular...
3.
Benin B, Hillyer T, Crugnale A, Fulk A, Thomas C, Crowder M, et al.
Microorganisms
. 2023 Nov;
11(11).
PMID: 38004664
Among the various mechanisms that bacteria use to develop antibiotic resistance, the multiple expression of β-lactamases is particularly problematic, threatening public health and increasing patient mortality rates. Even if a...
4.
Thomas C, Cheng Z, Bethel C, Hujer A, Sturgill A, Onuoha K, et al.
Antimicrob Agents Chemother
. 2023 Oct;
67(11):e0071423.
PMID: 37874296
β-Lactam antibiotics are among the most frequently prescribed therapeutic agents. A common mechanism of resistance toward β-lactam antibiotics is the production of β-lactamases. These enzymes are capable of hydrolyzing the...
5.
Characterizing bourbon whiskey via the combination of LC-MS and GC-MS based molecular fingerprinting
Xu R, Chen L, Zhang H, Crowder M, Zhu J
Food Chem
. 2023 May;
423:136311.
PMID: 37167670
To discover molecular fingerprints that vary by bourbon's age or color, 121 commercial bourbon samples were analyzed using both gas chromatography and liquid chromatography combined with mass spectrometry. In total,...
6.
Legru A, Verdirosa F, Vo-Hoang Y, Tassone G, Vascon F, Thomas C, et al.
J Med Chem
. 2022 Nov;
65(24):16392-16419.
PMID: 36450011
Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to preserve these important antibacterial drugs. Here, we describe...
7.
Discovery of an Effective Small-Molecule Allosteric Inhibitor of New Delhi Metallo-β-lactamase (NDM)
Thomas P, Cho E, Bethel C, Smisek T, Ahn Y, Schroeder J, et al.
ACS Infect Dis
. 2022 Mar;
8(4):811-824.
PMID: 35353502
To identify novel inhibitors of the carbapenemase New Delhi metallo-β-lactamase (NDM) as possible therapeutic compounds, we conducted a high-throughput screen of a 43,358-compound library. One of these compounds, a 2-quinazolinone...
8.
Legru A, Verdirosa F, Hernandez J, Tassone G, Sannio F, Benvenuti M, et al.
Eur J Med Chem
. 2021 Oct;
226:113873.
PMID: 34626878
Metallo-β-lactamases (MBLs) are important contributors of Gram-negative bacteria resistance to β-lactam antibiotics. MBLs are highly worrying because of their carbapenemase activity, their rapid spread in major human opportunistic pathogens while...
9.
Shin W, Nguyen M, Bergstrom A, Jennings I, Crowder M, Muthyala R, et al.
Chem Biol Drug Des
. 2021 Jun;
98(4):481-492.
PMID: 34148302
Metallo-β-lactamases (MBLs) are zinc-containing carbapenemases that inactivate a broad range of β-lactam antibiotics. There is a lack of β-lactamase inhibitors for restoring existing β-lactam antibiotics arsenals against common bacterial infections....
10.
Mehaffey M, Ahn Y, Rivera D, Thomas P, Cheng Z, Crowder M, et al.
Chem Sci
. 2021 Jun;
11(33):8999-9010.
PMID: 34123154
We use mass spectrometry (MS), under denaturing and non-denaturing solution conditions, along with ultraviolet photodissociation (UVPD) to characterize structural variations in New Delhi metallo-β-lactamase (NDM) upon perturbation by ligands or...