Chemical Biology & Drug Design
Overview
Chemical Biology & Drug Design is a reputable scientific journal that focuses on the interdisciplinary field of chemical biology and drug discovery. It publishes cutting-edge research articles, reviews, and perspectives that explore the design, synthesis, and evaluation of novel chemical compounds for therapeutic applications. The journal serves as a platform for scientists and researchers to share their findings and advancements in the development of new drugs and therapeutic strategies.
Details
Details
Abbr.
Chem Biol Drug Des
Start
2006
End
Continuing
Frequency
Monthly
p-ISSN
1747-0277
e-ISSN
1747-0285
Country
United Kingdom
Language
English
Specialties
Biochemistry
Pharmacology
Pharmacology
Metrics
Metrics
h-index / Ranks: 3601
91
SJR / Ranks: 7794
579
CiteScore / Ranks: 4133
5.70
JIF / Ranks: 3481
3.0
Recent Articles
1.
Knetsch T, van Son H, Kobayashi M, Ubbink M
Chem Biol Drug Des
. 2025 Mar;
105(3):e70080.
PMID: 40087816
Membrane proteins (MPs) are important yet challenging targets for drug discovery. MPs can be reconstituted in protein-lipid Nanodiscs (NDs), which resemble the native membrane environment. Drug-membrane interactions can affect the...
2.
Siddiq H, Imam M, Alsharif S, Attar R, Almughathawi R, Alshammari N, et al.
Chem Biol Drug Des
. 2025 Mar;
105(3):e70090.
PMID: 40087811
Twelve thiazole-pyrazole analogues 4, 6, and 8 were synthesized by introducing various pyrazole systems into the core, 2-((4-acetylphenyl)amino)-4-methylthiazole (2), through many synthetic approaches. The density functional theory (DFT) study of...
3.
Pyrrole-Tethered Bisbenzoxazole Derivatives: Apoptosis-Inducing Agents Targeting Breast Cancer Cells
Kuzu B, Yetkin D, Hepokur C, Algul O
Chem Biol Drug Des
. 2025 Mar;
105(3):e70078.
PMID: 40079412
This study presents the design, synthesis, and biological evaluation of a series of novel pyrrole-tethered bisbenzoxazole (PTB) derivatives as potential apoptosis-inducing agents targeting the MCF-7 human breast cancer cell line....
4.
Liu Q, Luo A, Jin H, Si X, Li M
Chem Biol Drug Des
. 2025 Mar;
105(3):e70084.
PMID: 40077992
The bacterial cell wall is crucial for maintaining the integrity of bacterial cells. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in bacterial cell wall synthesis. Therefore, it is...
5.
Thottasseri A, Rajendran V, Ramesh D, Tom A, Thomas R, Ray S, et al.
Chem Biol Drug Des
. 2025 Mar;
105(3):e70081.
PMID: 40070234
Malaria is a pervasive and deadly threat to the global population, and the resources available to treat this disease are limited. There is widespread clinical resistance to the most commonly...
6.
Moscatilin Induces Ferroptosis in Clear Cell Renal Cell Carcinoma via the JAK-STAT Signaling Pathway
Chen P, Yang J, Chen L, Liu C, Li Z, Long X, et al.
Chem Biol Drug Des
. 2025 Mar;
105(3):e70071.
PMID: 40070232
Moscatilin, a biphenyl compound derived from Dendrobium nobile, exhibits significant anti-tumor activity. However, the specific role of moscatilin in clear cell renal cell carcinoma (ccRCC) and its underlying molecular mechanisms...
7.
Jiao F, Wang P, Zeng D, Bao Y, Zhang Y, Tao J, et al.
Chem Biol Drug Des
. 2025 Mar;
105(3):e70088.
PMID: 40070213
Methicillin-resistant Staphylococcus aureus (MRSA) achieves high-level resistance against β-lactam antibiotics through the expression of penicillin-binding protein 2a (PBP2a), which features a closed active site that impedes antibiotic binding. Herein, we...
8.
Shen H, Yu G, Cai T, Hu K, Shang T, Luo Y, et al.
Chem Biol Drug Des
. 2025 Mar;
105(3):e70082.
PMID: 40047283
Parkinson's disease (PD) is the second most common neurodegenerative disease but has limited medications. Targeting leucine-rich repeat kinase 2 (LRRK2) has been identified as a potential strategy for the treatment...
9.
Singh S, Kumar R, Tripathi S, Salahuddin , Mazumder A, Singh N
Chem Biol Drug Des
. 2025 Mar;
105(3):e70077.
PMID: 40047279
Cancer is an abnormal and uncontrolled proliferation of normal cells. The availability of safer anticancer drugs with exceptional selectivity for healthy cells and great efficacy against various cancer forms continues...
10.
He B, Tan H, Liu C, Wu H, He L
Chem Biol Drug Des
. 2025 Mar;
105(3):e70079.
PMID: 40047275
A novel class of chalcone Mannich base derivatives I and II was synthesized, which exhibited significant antiproliferation activities in five different cancer cells. The activities of most compounds were superior...