Michael S Bonkowski
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Explore the profile of Michael S Bonkowski including associated specialties, affiliations and a list of published articles.
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2267
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Recent Articles
11.
Bonkowski M, Sinclair D
Nat Rev Mol Cell Biol
. 2016 Aug;
17(11):679-690.
PMID: 27552971
The sirtuins (SIRT1-7) are a family of nicotinamide adenine dinucleotide (NAD)-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing. Mice engineered to express additional copies...
12.
Cagnone G, Tsai T, Makanji Y, Matthews P, Gould J, Bonkowski M, et al.
Sci Rep
. 2016 Mar;
6:23229.
PMID: 26987907
An increasing number of women fail to achieve pregnancy due to either failed fertilization or embryo arrest during preimplantation development. This often results from decreased oocyte quality. Indeed, reduced mitochondrial...
13.
Koopman J, van Heemst D, van Bodegom D, Bonkowski M, Sun L, Bartke A
Aging (Albany NY)
. 2016 Mar;
8(3):539-46.
PMID: 26959761
Caloric restriction and genetic disruption of growth hormone signaling have been shown to counteract aging in mice. The effects of these interventions on aging are examined through age-dependent survival or...
14.
Abdesselem H, Madani A, Hani A, Al-Noubi M, Goswami N, Hamidane H, et al.
J Biol Chem
. 2015 Dec;
291(5):2119-35.
PMID: 26655722
The expansion of fat mass in the obese state is due to increased adipocyte hypertrophy and hyperplasia. The molecular mechanism that drives adipocyte hyperplasia remains unknown. The NAD(+)-dependent protein deacetylase...
15.
Westbrook R, Bonkowski M, Arum O, Strader A, Bartke A
J Gerontol A Biol Sci Med Sci
. 2013 Jul;
69(1):25-33.
PMID: 23833202
Mutations causing decreased somatotrophic signaling are known to increase insulin sensitivity and extend life span in mammals. Caloric restriction and every other day (EOD) dietary regimens are associated with similar...
16.
Libert S, Bonkowski M, Pointer K, Pletcher S, Guarente L
Aging Cell
. 2012 Jun;
11(5):794-800.
PMID: 22702406
The variation of individual life spans, even in highly inbred cohorts of animals and under strictly controlled environmental conditions, is substantial and not well understood. This variation in part could...
17.
Cohen D, Supinski A, Bonkowski M, Donmez G, Guarente L
Genes Dev
. 2009 Dec;
23(24):2812-7.
PMID: 20008932
Mammalian life span can be extended by both calorie restriction (CR) and mutations that diminish somatotropic signaling. Sirt1 is a mediator of many effects of CR in mammals, but any...
18.
Arum O, Bonkowski M, Rocha J, Bartke A
Aging Cell
. 2009 Sep;
8(6):756-60.
PMID: 19747233
The interaction of longevity-conferring genes with longevity-conferring diets is poorly understood. The growth hormone receptor gene-disrupted (GHR-KO) mouse is long lived; and this longevity is not responsive to 30% caloric...
19.
Panici J, Wang F, Bonkowski M, Spong A, Bartke A, Pawlikowska L, et al.
J Gerontol A Biol Sci Med Sci
. 2009 Aug;
64(11):1126-33.
PMID: 19706698
Growth hormone receptor knockout (GHRKO) mice live about 40%-55% longer than their normal (N) littermates. Previous studies of 21-month-old GHRKO and N mice showed major alterations of the hepatic expression...
20.
Masternak M, Panici J, Bonkowski M, Hughes L, Bartke A
J Gerontol A Biol Sci Med Sci
. 2009 Mar;
64(5):516-21.
PMID: 19304940
Reduced insulin sensitivity and glucose intolerance have been long suspected of having important involvement in aging. Here we report that in studies of calorie restriction (CR) effects in mutant (Prop1(df)...