Jacob A Panici
Overview
Explore the profile of Jacob A Panici including associated specialties, affiliations and a list of published articles.
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12
Citations
422
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Recent Articles
1.
Panici J, Harper J, Miller R, Bartke A, Spong A, Masternak M
FASEB J
. 2010 Aug;
24(12):5073-9.
PMID: 20720157
Hypopituitary Ames dwarf mice were injected either with growth hormone (GH) or thyroxine for a 6-wk period to see whether this intervention would reverse their long life span or the...
2.
Masternak M, Panici J, Wang F, Wang Z, Spong A
J Gerontol A Biol Sci Med Sci
. 2009 Nov;
65(1):24-30.
PMID: 19906822
The disruption of the growth hormone (GH) axis in mice promotes insulin sensitivity and is strongly correlated with extended longevity. Ames dwarf (Prop1(df), df/df) mice are GH, prolactin (PRL), and...
3.
Panici J, Wang F, Bonkowski M, Spong A, Bartke A, Pawlikowska L, et al.
J Gerontol A Biol Sci Med Sci
. 2009 Aug;
64(11):1126-33.
PMID: 19706698
Growth hormone receptor knockout (GHRKO) mice live about 40%-55% longer than their normal (N) littermates. Previous studies of 21-month-old GHRKO and N mice showed major alterations of the hepatic expression...
4.
Masternak M, Panici J, Bonkowski M, Hughes L, Bartke A
J Gerontol A Biol Sci Med Sci
. 2009 Mar;
64(5):516-21.
PMID: 19304940
Reduced insulin sensitivity and glucose intolerance have been long suspected of having important involvement in aging. Here we report that in studies of calorie restriction (CR) effects in mutant (Prop1(df)...
5.
Jimenez-Ortega V, Masternak M, Panici J, Wang Z, Bartke A, Esquifino A
Exp Biol Med (Maywood)
. 2008 Mar;
233(4):434-8.
PMID: 18367632
Transgenic mice overexpressing human growth hormone (hGH) exhibit accelerated aging with functional hyperprolactinemia and greatly depressed endogenous prolactin. Calorie restriction (CR) is widely recognized as the most effective experimental intervention...
6.
A Al-Regaiey K, Masternak M, Bonkowski M, Panici J, Kopchick J, Bartke A
J Gerontol A Biol Sci Med Sci
. 2007 Feb;
62(1):18-26.
PMID: 17301033
Growth hormone receptor-deficient (GHRKO) mice are long-lived and have reduced insulin-like growth factor (IGF)-1 and insulin levels and enhanced insulin sensitivity thus resembling the phenotype of animals subjected to calorie...
7.
Bonkowski M, Pamenter R, Rocha J, Masternak M, Panici J, Bartke A
J Gerontol A Biol Sci Med Sci
. 2006 Jun;
61(6):562-7.
PMID: 16799137
There is conflicting information on the physiological role of growth hormone (GH) in the control of aging. This study reports dual-energy x-ray absorptiometry (DXA) measurements of body composition and bone...
8.
Masternak M, A Al-Regaiey K, Lim M, Jimenez-Ortega V, Panici J, Bonkowski M, et al.
Exp Gerontol
. 2006 Mar;
41(4):417-29.
PMID: 16524678
Blockade of growth hormone (GH), decreased insulin-like growth factor-1 (IGF1) action and increased insulin sensitivity are associated with life extension and an apparent slowing of the aging process. We examined...
9.
Masternak M, A Al-Regaiey K, Lim M, Jimenez-Ortega V, Panici J, Bonkowski M, et al.
J Gerontol A Biol Sci Med Sci
. 2005 Dec;
60(11):1394-8.
PMID: 16339324
Growth hormone receptor/binding protein knockout (GHR-KO) mice live approximately 40% longer than their normal siblings do. These mice have dramatically reduced plasma levels of insulin-like growth factor 1 (IGF1) and...
10.
Masternak M, A Al-Regaiey K, Lim M, Bonkowski M, Panici J, Przybylski G, et al.
J Gerontol A Biol Sci Med Sci
. 2005 Nov;
60(10):1238-45.
PMID: 16282554
Resistance to growth hormone, reduced insulin-like growth factor 1 (IGF1) action, and enhanced insulin sensitivity are likely mediators of extended life span and delayed aging process in growth hormone receptor/binding...