Randy Strich
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Explore the profile of Randy Strich including associated specialties, affiliations and a list of published articles.
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48
Citations
1125
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Recent Articles
1.
Heilmann R, Pfalzer A, Bichell T, Terala A, Campbell A, Taatjes D, et al.
Ther Adv Rare Dis
. 2024 Dec;
5:26330040241290252.
PMID: 39619418
A strategic research plan (SRP) serves as a compass for the patient advocacy organizations driving the therapeutic options for their rare disorder. The MED13L Foundation commissioned the SRP in 2022...
2.
Hanley S, Willis S, Doyle S, Strich R, Cooper K
Autophagy
. 2023 Sep;
20(2):397-415.
PMID: 37733395
Ksp1 is a casein II-like kinase whose activity prevents aberrant macroautophagy/autophagy induction in nutrient-rich conditions in yeast. Here, we describe a kinase-independent role of Ksp1 as a novel autophagic receptor...
3.
Song Z, Xiaoli A, Li Y, Siqin G, Wu T, Strich R, et al.
Mol Metab
. 2022 Jul;
64:101548.
PMID: 35863637
Objective: Cyclin C (CCNC) is the most conserved subunit of the Mediator complex, which is an important transcription cofactor. Recently, we have found that CCNC facilitates brown adipogenesis in vitro...
4.
Willis S, Hanley S, Doyle S, Beluch K, Strich R, Cooper K
Front Cell Dev Biol
. 2022 Apr;
10:867257.
PMID: 35433688
Cells facing adverse environmental cues respond by inducing signal transduction pathways resulting in transcriptional reprograming. In the budding yeast , nutrient deprivation stimulates stress response gene (SRG) transcription critical for...
5.
Chang K, Jezek J, Campbell A, Stieg D, Kiss Z, Kemper K, et al.
iScience
. 2022 Feb;
25(2):103823.
PMID: 35198885
syndrome is a haploinsufficiency developmental disorder characterized by intellectual disability, heart malformation, and hypotonia. MED13L controls transcription by tethering the cyclin C-Cdk8 kinase module (CKM) to the Mediator complex. In...
6.
Jezek J, Cooper K, Strich R
Biology (Basel)
. 2021 Jan;
10(1).
PMID: 33418995
Cancer is one of the world's deadliest afflictions. Despite recent advances in diagnostic and surgical technologies, as well as improved treatments of some individual tumor types, there is currently no...
7.
Stieg D, Cooper K, Strich R
J Biol Chem
. 2020 Sep;
295(48):16280-16291.
PMID: 32934007
The Cdk8 kinase module (CKM) is a detachable Mediator subunit composed of cyclin C and one each of paralogs Cdk8/Cdk19, Med12/Med12L, and Med13/Med13L. Our previous RNA-Seq studies demonstrated that cyclin...
8.
Jezek J, Chang K, Joshi A, Strich R
EMBO Rep
. 2019 Aug;
20(9):e47425.
PMID: 31385392
Intrinsic apoptosis requires mitochondrial outer membrane disruption triggered by recruitment, activation, and oligomerization of the Bcl-2 homology protein Bax. Following oxidative stress, we demonstrated that the transcriptional regulator cyclin C...
9.
Jezek J, Wang K, Yan R, Di Cristofano A, Cooper K, Strich R
J Cell Sci
. 2019 Jul;
132(16).
PMID: 31331961
The cyclin C-Cdk8 kinase has been identified as both a tumor suppressor and an oncogene depending on the cell type. The genomic locus encoding cyclin C () is often deleted...
10.
Stieg D, Chang K, Cooper K, Strich R
G3 (Bethesda)
. 2019 May;
9(6):1901-1908.
PMID: 31036676
The transcriptional changes that occur in response to oxidative stress help direct the decision to maintain cell viability or enter a cell death pathway. Cyclin C-Cdk8 is a conserved kinase...