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Michael J Mallory

Explore the profile of Michael J Mallory including associated specialties, affiliations and a list of published articles. Areas
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Articles 29
Citations 831
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Recent Articles
11.
Cole B, Tapescu I, Allon S, Mallory M, Qiu J, Lake R, et al.
RNA . 2015 Oct; 21(12):2053-66. PMID: 26437669
HnRNP L is a ubiquitous splicing-regulatory protein that is critical for the development and function of mammalian T cells. Previous work has identified a few targets of hnRNP L-dependent alternative...
12.
Yarosh C, Tapescu I, Thompson M, Qiu J, Mallory M, Fu X, et al.
Nucleic Acids Res . 2015 Aug; 43(18):9006-16. PMID: 26261210
PSF (a.k.a. SFPQ) is a ubiquitously expressed, essential nuclear protein with important roles in DNA damage repair and RNA biogenesis. In stimulated T cells, PSF binds to and suppresses the...
13.
Mallory M, Allon S, Qiu J, Gazzara M, Tapescu I, Martinez N, et al.
Proc Natl Acad Sci U S A . 2015 Apr; 112(17):E2139-48. PMID: 25870297
Studies in several cell types have highlighted dramatic and diverse changes in mRNA processing that occur upon cellular stimulation. However, the mechanisms and pathways that lead to regulated changes in...
14.
Motta-Mena L, Reade A, Mallory M, Glantz S, Weiner O, Lynch K, et al.
Nat Chem Biol . 2014 Jan; 10(3):196-202. PMID: 24413462
Optogenetic gene expression systems can control transcription with spatial and temporal detail unequaled with traditional inducible promoter systems. However, current eukaryotic light-gated transcription systems are limited by toxicity, dynamic range...
15.
Law M, Mallory M, Dunbrack Jr R, Strich R
Mol Cell Biol . 2013 Dec; 34(4):631-42. PMID: 24298021
Differentiation programs require strict spatial and temporal control of gene transcription. Genes expressed during meiotic development in Saccharomyces cerevisiae display transient induction and repression. Early meiotic gene (EMG) repression during...
16.
Smith S, Ray D, Cook K, Mallory M, Hughes T, Lynch K
PLoS One . 2013 Nov; 8(11):e80701. PMID: 24244709
HnRNP (heterogeneous nuclear ribonucleoprotein) proteins are a large family of RNA-binding proteins that regulate numerous aspects of RNA processing. Interestingly, several paralogous pairs of hnRNPs exist that exhibit similar RNA-binding...
17.
Shankarling G, Cole B, Mallory M, Lynch K
Mol Cell Biol . 2013 Oct; 34(1):71-83. PMID: 24164894
The RNA processing factor hnRNP L is required for T cell development and function. However, the spectrum of direct targets of hnRNP L activity in T cells has yet to...
18.
Tan G, Lewandowski R, Mallory M, Strich R, Cooper K
Cell Div . 2013 Jul; 8(1):9. PMID: 23816140
Background: The execution of meiotic nuclear divisions in S. cerevisiae is regulated by protein degradation mediated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase. The correct timing of APC/C activity...
19.
Mallory M, Law M, Sterner D, Berger S, Strich R
Mol Biol Cell . 2012 Mar; 23(9):1609-17. PMID: 22438583
Ume6p represses early meiotic gene transcription in Saccharomyces cerevisiae by recruiting the Rpd3p histone deacetylase and chromatin-remodeling proteins. Ume6p repression is relieved in a two-step destruction process mediated by the...
20.
Cooper K, Scarnati M, Krasley E, Mallory M, Jin C, Law M, et al.
J Cell Sci . 2012 Mar; 125(Pt 4):1015-26. PMID: 22421358
The yeast cyclin-C-Cdk8p kinase complex represses the transcription of a subset of genes involved in the stress response. To relieve this repression, cyclin C is destroyed in cells exposed to...