Matthew G Thompson
Overview
Explore the profile of Matthew G Thompson including associated specialties, affiliations and a list of published articles.
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17
Citations
211
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Recent Articles
1.
Gokhale N, Sam R, Somfleth K, Thompson M, Marciniak D, Smith J, et al.
Science
. 2024 Dec;
386(6728):eadl0429.
PMID: 39700280
Antiviral signaling downstream of RIG-I-like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein complex function can be modulated by RNA...
2.
Horner S, Thompson M
RNA
. 2024 Mar;
30(5):482-490.
PMID: 38531643
Viral RNA molecules contain multiple layers of regulatory information. This includes features beyond the primary sequence, such as RNA structures and RNA modifications, including N6-methyladenosine (mA). Many recent studies have...
3.
Marayati B, Thompson M, Holley C, Horner S, Meyer K
Nat Biotechnol
. 2024 Jan;
42(9):1417-1428.
PMID: 38168988
The N-methyladenosine (mA) modification is found in thousands of cellular mRNAs and is a critical regulator of gene expression and cellular physiology. mA dysregulation contributes to several human diseases, and...
4.
Thompson M, Horner S
Mol Cell
. 2023 Nov;
83(22):3948-3949.
PMID: 37977114
In this issue, Tapescu et al. identify DDX39A as a novel antiviral protein that acts on conserved features of alphavirus RNA to limit infection in an IFN-independent manner.
5.
Gokhale N, Somfleth K, Thompson M, Sam R, Marciniak D, Chu L, et al.
bioRxiv
. 2023 Oct;
PMID: 37808873
Immune signaling needs to be well-regulated to promote clearance of pathogens, while preventing aberrant inflammation. Interferons (IFNs) and antiviral genes are activated by the detection of viral RNA by RIG-I-like...
6.
Thompson M, Sacco M, Horner S
Immunol Rev
. 2021 Aug;
304(1):169-180.
PMID: 34405413
Induction of the antiviral innate immune response is highly regulated at the RNA level, particularly by RNA modifications. Recent discoveries have revealed how RNA modifications play key roles in cellular...
7.
Thompson M, Dittmar M, Mallory M, Bhat P, Ferretti M, Fontoura B, et al.
Elife
. 2020 Dec;
9.
PMID: 33269701
Viral infection induces the expression of numerous host genes that impact the outcome of infection. Here, we show that infection of human lung epithelial cells with influenza A virus (IAV)...
8.
Thompson M, Lynch K
Cold Spring Harb Symp Quant Biol
. 2020 Jul;
84:123-131.
PMID: 32703803
Alternative splicing is a pervasive gene regulatory mechanism utilized by both mammalian cells and viruses to expand their genomic coding capacity. The process of splicing and the RNA sequences that...
9.
Zhang K, Shang G, Padavannil A, Wang J, Sakthivel R, Chen X, et al.
Proc Natl Acad Sci U S A
. 2018 Dec;
115(52):E12218-E12227.
PMID: 30538201
The influenza virulence factor NS1 protein interacts with the cellular NS1-BP protein to promote splicing and nuclear export of the viral M mRNAs. The viral M1 mRNA encodes the M1...
10.
Thompson M, Munoz-Moreno R, Bhat P, Roytenberg R, Lindberg J, Gazzara M, et al.
Nat Commun
. 2018 Jun;
9(1):2407.
PMID: 29921878
Three of the eight RNA segments encoded by the influenza A virus (IAV) undergo alternative splicing to generate distinct proteins. Previously, we found that host proteins hnRNP K and NS1-BP...