Michael Alexanian
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Explore the profile of Michael Alexanian including associated specialties, affiliations and a list of published articles.
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Citations
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Recent Articles
11.
Alexanian M, Przytycki P, Micheletti R, Padmanabhan A, Ye L, Travers J, et al.
Nature
. 2021 Jun;
595(7867):438-443.
PMID: 34163071
In diseased organs, stress-activated signalling cascades alter chromatin, thereby triggering maladaptive cell state transitions. Fibroblast activation is a common stress response in tissues that worsens lung, liver, kidney and heart...
12.
Shim W, Sinniah E, Xu J, Vitrinel B, Alexanian M, Andreoletti G, et al.
Cell Syst
. 2020 Dec;
11(6):625-639.e13.
PMID: 33278344
Determining genes that orchestrate cell differentiation in development and disease remains a fundamental goal of cell biology. This study establishes a genome-wide metric based on the gene-repressive trimethylation of histone...
13.
Padmanabhan A, Alexanian M, Linares-Saldana R, Gonzalez-Teran B, Andreoletti G, Huang Y, et al.
Circulation
. 2020 Oct;
142(24):2338-2355.
PMID: 33094644
Background: Gene regulatory networks control tissue homeostasis and disease progression in a cell type-specific manner. Ubiquitously expressed chromatin regulators modulate these networks, yet the mechanisms governing how tissue specificity of...
14.
Alexanian M, Haldar S
J Clin Invest
. 2020 Aug;
130(9):4536-4539.
PMID: 32773407
Heart failure (HF) with reduced contractile function is a common and lethal syndrome in which the heart cannot pump blood to adequately meet bodily demands, resulting in high mortality despite...
15.
Alexanian M, Ounzain S
Cold Spring Harb Perspect Biol
. 2020 Jan;
12(11).
PMID: 31932317
The exquisite transcriptional control of developmental gene programs is critical for hardwiring the complex expression patterns that govern cell-fate determination and differentiation during heart development. During the past several years,...
16.
Stratton M, Bagchi R, Felisbino M, Hirsch R, Smith H, Riching A, et al.
Circ Res
. 2019 Aug;
125(7):662-677.
PMID: 31409188
Rationale: Small molecule inhibitors of the acetyl-histone binding protein BRD4 have been shown to block cardiac fibrosis in preclinical models of heart failure (HF). However, since the inhibitors target BRD4...
17.
Alexanian M, Padmanabhan A, McKinsey T, Haldar S
J Mol Cell Cardiol
. 2019 Apr;
130:197-204.
PMID: 30991033
Heart failure (HF) is a dominant cause of morbidity and mortality in the developed world, with available pharmacotherapies limited by high rates of residual mortality and a failure to directly...
18.
19.
Alexanian M, Maric D, Jenkinson S, Mina M, Friedman C, Ting C, et al.
Nat Commun
. 2017 Nov;
8(1):1806.
PMID: 29180618
Enhancers and long noncoding RNAs (lncRNAs) are key determinants of lineage specification during development. Here, we evaluate remodeling of the enhancer landscape and modulation of the lncRNA transcriptome during mesendoderm...
20.
Micheletti R, Plaisance I, Abraham B, Sarre A, Ting C, Alexanian M, et al.
Sci Transl Med
. 2017 Jun;
9(395).
PMID: 28637928
Long noncoding RNAs (lncRNAs) are emerging as powerful regulators of cardiac development and disease. However, our understanding of the importance of these molecules in cardiac fibrosis is limited. Using an...