Deepak Srivastava
Overview
Explore the profile of Deepak Srivastava including associated specialties, affiliations and a list of published articles.
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Articles
201
Citations
17582
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Recent Articles
1.
Dong W, Jin S, Sierant M, Lu Z, Li B, Lu Q, et al.
Proc Natl Acad Sci U S A
. 2025 Mar;
122(10):e2419992122.
PMID: 40030011
Variants with large effect contribute to congenital heart disease (CHD). To date, recessive genotypes (RGs) have commonly been implicated through anecdotal ascertainment of consanguineous families and candidate gene-based analysis; the...
2.
Abdulai-Saiku S, Gupta S, Wang D, Marino F, Moreno A, Huang Y, et al.
Nature
. 2025 Jan;
638(8049):152-159.
PMID: 39843739
Female mammalian cells have two X chromosomes, one of maternal origin and one of paternal origin. During development, one X chromosome randomly becomes inactivated. This renders either the maternal X...
3.
Alexanian M, Padmanabhan A, Nishino T, Travers J, Ye L, Pelonero A, et al.
Nature
. 2024 Oct;
635(8038):434-443.
PMID: 39443808
Chronic inflammation and tissue fibrosis are common responses that worsen organ function, yet the molecular mechanisms governing their cross-talk are poorly understood. In diseased organs, stress-induced gene expression changes fuel...
4.
Padmanabhan A, de Soysa T, Pelonero A, Sapp V, Shah P, Wang Q, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(3):317-331.
PMID: 39196112
Human induced pluripotent stem cell (hiPSC) to cardiomyocyte (CM) differentiation has reshaped approaches to studying cardiac development and disease. In this study, we employed a genome-wide CRISPR screen in a...
5.
Nishino T, Ranade S, Pelonero A, van Soldt B, Ye L, Alexanian M, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(12):1190-1203.
PMID: 39183978
Maternal diabetes mellitus is among the most frequent environmental contributors to congenital birth defects, including heart defects and craniofacial anomalies, yet the cell types affected and mechanisms of disruption are...
6.
Zholudeva L, Fortino T, Agrawal A, Vila O, Williams M, McDevitt T, et al.
bioRxiv
. 2024 Jan;
PMID: 38260390
Advances in cell therapy offer promise for some of the most devastating neural injuries, including spinal cord injury (SCI). Endogenous VSX2-expressing spinal V2a interneurons have been implicated as a key...
7.
Maven B, Gifford C, Weilert M, Gonzalez-Teran B, Huttenhain R, Pelonero A, et al.
Stem Cell Reports
. 2023 Oct;
18(11):2138-2153.
PMID: 37863045
Congenital heart disease often arises from perturbations of transcription factors (TFs) that guide cardiac development. ISLET1 (ISL1) is a TF that influences early cardiac cell fate, as well as differentiation...
8.
Zhou H, Yang J, Srinath C, Zeng A, Wu I, Leon E, et al.
Circulation
. 2023 Aug;
148(14):1099-1112.
PMID: 37602409
Background: Cardiac reprogramming is a technique to directly convert nonmyocytes into myocardial cells using genes or small molecules. This intervention provides functional benefit to the rodent heart when delivered at...
9.
Jang M, Patel P, Pereira A, Willcox J, Haghighi A, Tai A, et al.
Circ Genom Precis Med
. 2023 May;
16(3):224-231.
PMID: 37165897
Background: Known genetic causes of congenital heart disease (CHD) explain <40% of CHD cases, and interpreting the clinical significance of variants with uncertain functional impact remains challenging. We aim to...
10.
Yu M, Aguirre M, Jia M, Gjoni K, Cordova-Palomera A, Munger C, et al.
Circ Genom Precis Med
. 2023 Apr;
16(3):258-266.
PMID: 37026454
Background: Congenital heart disease (CHD) is highly heritable, but the power to identify inherited risk has been limited to analyses of common variants in small cohorts. Methods: We performed reimputation...