Saptarsi M Haldar
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Explore the profile of Saptarsi M Haldar including associated specialties, affiliations and a list of published articles.
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61
Citations
2169
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Recent Articles
1.
Amrute J, Lee P, Eres I, Lee C, Bredemeyer A, Sheth M, et al.
medRxiv
. 2024 Nov;
PMID: 39606421
Although genome wide association studies (GWAS) in large populations have identified hundreds of variants associated with common diseases such as coronary artery disease (CAD), most disease-associated variants lie within non-coding...
2.
Alexanian M, Padmanabhan A, Nishino T, Travers J, Ye L, Pelonero A, et al.
Nature
. 2024 Oct;
635(8038):434-443.
PMID: 39443808
Chronic inflammation and tissue fibrosis are common responses that worsen organ function, yet the molecular mechanisms governing their cross-talk are poorly understood. In diseased organs, stress-induced gene expression changes fuel...
3.
Durumutla H, Prabakaran A, Soussi F, Akinborewa O, Latimer H, McFarland K, et al.
JCI Insight
. 2024 Oct;
9(22).
PMID: 39378111
Circadian time of intake gates the cardioprotective effects of glucocorticoid administration in both healthy and infarcted hearts. The cardiomyocyte-specific glucocorticoid receptor (GR) and its cofactor, Krüppel-like factor 15 (KLF15), play...
4.
Padmanabhan A, de Soysa T, Pelonero A, Sapp V, Shah P, Wang Q, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(3):317-331.
PMID: 39196112
Human induced pluripotent stem cell (hiPSC) to cardiomyocyte (CM) differentiation has reshaped approaches to studying cardiac development and disease. In this study, we employed a genome-wide CRISPR screen in a...
5.
Berger J, Matsuura T, Bowman C, Taing R, Patel J, Lai L, et al.
Circ Res
. 2024 Jul;
135(5):632-634.
PMID: 39041214
No abstract available.
6.
Berger J, Matsuura T, Bowman C, Taing R, Patel J, Lai L, et al.
bioRxiv
. 2024 May;
PMID: 38746425
Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are novel, potent heart failure medications with an unknown mechanism of action. We sought to determine if the beneficial actions of SGLT2i in heart failure...
7.
8.
Durumutla H, Prabakaran A, Soussi F, Akinborewa O, Latimer H, McFarland K, et al.
bioRxiv
. 2024 Jan;
PMID: 38187555
Circadian time-of-intake gates the cardioprotective effects of glucocorticoid administration in both healthy and infarcted hearts. The cardiomyocyte-specific glucocorticoid receptor (GR) and its co-factor, Krüppel-like factor (Klf15), play critical roles in...
9.
Alexanian M, Padmanabhan A, Nishino T, Travers J, Ye L, Lee C, et al.
bioRxiv
. 2023 Jan;
PMID: 36711864
Chronic inflammation and tissue fibrosis are common stress responses that worsen organ function, yet the molecular mechanisms governing their crosstalk are poorly understood. In diseased organs, stress-induced changes in gene...
10.
Hsu A, Duan Q, Day D, Luo X, McMahon S, Huang Y, et al.
Nat Commun
. 2022 Jul;
13(1):4345.
PMID: 35896549
Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality, highlighting an urgent need for new therapeutic strategies. As stress-activated cardiac signaling cascades converge on the nucleus to...