Michael Alexanian
Overview
Explore the profile of Michael Alexanian including associated specialties, affiliations and a list of published articles.
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24
Citations
902
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Recent Articles
1.
Schuetze K, Stratton M, Bagchi R, Hobby A, Felisbino M, Rubino M, et al.
Am J Physiol Heart Circ Physiol
. 2024 Dec;
328(2):H294-H309.
PMID: 39716819
Bromodomain and extraterminal domain (BET) proteins, including BRD4, bind acetylated chromatin and coactivate gene transcription. A BET inhibitor, JQ1, prevents and reverses pathological cardiac remodeling in preclinical models of heart...
2.
Alexanian M, Padmanabhan A, Nishino T, Travers J, Ye L, Pelonero A, et al.
Nature
. 2024 Oct;
635(8038):434-443.
PMID: 39443808
Chronic inflammation and tissue fibrosis are common responses that worsen organ function, yet the molecular mechanisms governing their cross-talk are poorly understood. In diseased organs, stress-induced gene expression changes fuel...
3.
Padmanabhan A, de Soysa T, Pelonero A, Sapp V, Shah P, Wang Q, et al.
Nat Cardiovasc Res
. 2024 Aug;
3(3):317-331.
PMID: 39196112
Human induced pluripotent stem cell (hiPSC) to cardiomyocyte (CM) differentiation has reshaped approaches to studying cardiac development and disease. In this study, we employed a genome-wide CRISPR screen in a...
4.
Nishino T, Ranade S, Pelonero A, van Soldt B, Ye L, Alexanian M, et al.
Nat Cardiovasc Res
. 2024 Aug;
2(12):1190-1203.
PMID: 39183978
Maternal diabetes mellitus is among the most frequent environmental contributors to congenital birth defects, including heart defects and craniofacial anomalies, yet the cell types affected and mechanisms of disruption are...
5.
Alexanian M, Padmanabhan A, Nishino T, Travers J, Ye L, Lee C, et al.
bioRxiv
. 2023 Jan;
PMID: 36711864
Chronic inflammation and tissue fibrosis are common stress responses that worsen organ function, yet the molecular mechanisms governing their crosstalk are poorly understood. In diseased organs, stress-induced changes in gene...
6.
Micheletti R, Alexanian M
Biochem Soc Trans
. 2022 Oct;
50(5):1247-1255.
PMID: 36281993
Cardiac fibroblasts play an essential role in maintaining the structural framework of the heart. Upon stress, fibroblasts undergo a cell state transition to activated fibroblasts (also referred to as myofibroblasts),...
7.
Hsu A, Duan Q, Day D, Luo X, McMahon S, Huang Y, et al.
Nat Commun
. 2022 Jul;
13(1):4345.
PMID: 35896549
Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality, highlighting an urgent need for new therapeutic strategies. As stress-activated cardiac signaling cascades converge on the nucleus to...
8.
Jiang Z, Elsarrag S, Duan Q, LaGory E, Wang Z, Alexanian M, et al.
Sci Adv
. 2022 Mar;
8(10):eabj2917.
PMID: 35263131
Circulating corticosteroids orchestrate stress adaptation, including inhibition of inflammation. While pathways governing corticosteroid biosynthesis and intracellular signaling are well understood, less is known about mechanisms controlling plasma corticosteroid transport. Here,...
9.
Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Huttenhain R, et al.
Cell
. 2022 Feb;
185(5):794-814.e30.
PMID: 35182466
Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal mutations remains challenging. We hypothesized that genetic determinants for CHDs may lie in the protein...
10.
Silva A, Matthys O, Joy D, Kauss M, Natarajan V, Lai M, et al.
Cell Stem Cell
. 2021 Dec;
28(12):2137-2152.e6.
PMID: 34861147
During embryogenesis, paracrine signaling between tissues in close proximity contributes to the determination of their respective cell fate(s) and development into functional organs. Organoids are in vitro models that mimic...