Matt J Neville
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Explore the profile of Matt J Neville including associated specialties, affiliations and a list of published articles.
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5169
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Recent Articles
1.
Loh N, Vasan S, Rosoff D, Roberts E, van Dam A, Verma M, et al.
Commun Med (Lond)
. 2025 Feb;
5(1):51.
PMID: 40000740
Background: WNT signaling plays a key role in postnatal bone formation. Individuals with gain-of-function mutations in the WNT co-receptor LRP5 exhibit increased lower-body fat mass and potentially enhanced glucose metabolism,...
2.
Mi Y, Burnham K, Charles P, Heilig R, Vendrell I, Whalley J, et al.
Sci Transl Med
. 2024 Jun;
16(750):eadh0185.
PMID: 38838133
Sepsis, the dysregulated host response to infection causing life-threatening organ dysfunction, is a global health challenge requiring better understanding of pathophysiology and new therapeutic approaches. Here, we applied high-throughput tandem...
3.
Karjalainen M, Karthikeyan S, Oliver-Williams C, Sliz E, Allara E, Fung W, et al.
Nature
. 2024 Mar;
628(8006):130-138.
PMID: 38448586
Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism. This detailed knowledge of the genetic determinants of systemic metabolism has been...
4.
Graham S, Clarke S, Wu K, Kanoni S, Zajac G, Ramdas S, et al.
Nature
. 2023 May;
618(7965):E19-E20.
PMID: 37237109
No abstract available.
5.
Nagarajan S, Livingstone E, Monfeuga T, Lewis L, Ali S, Chandran A, et al.
Metabolism
. 2023 Apr;
144:155563.
PMID: 37088121
Background And Aim: Enhanced hepatic de novo lipogenesis (DNL) has been proposed as an underlying mechanism for the development of NAFLD and insulin resistance. Max-like protein factor X (MLX) acts...
6.
Kanoni S, Graham S, Wang Y, Surakka I, Ramdas S, Zhu X, et al.
Genome Biol
. 2022 Dec;
23(1):268.
PMID: 36575460
Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of...
7.
Pieri K, Trichia E, Neville M, Taylor H, Bennett D, Karpe F, et al.
Int J Cardiol
. 2022 Nov;
373:72-78.
PMID: 36410544
Background: Type III hyperlipidaemia (T3HL) is characterised by equimolar increases in plasma triglycerides (TG) and cholesterol in <10% of APOE22 carriers conveying high cardiovascular disease (CVD) risk. We investigate the...
8.
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, et al.
Nature
. 2022 Oct;
610(7933):704-712.
PMID: 36224396
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes. Here, using...
9.
Ramdas S, Judd J, Graham S, Kanoni S, Wang Y, Surakka I, et al.
Am J Hum Genet
. 2022 Aug;
109(8):1366-1387.
PMID: 35931049
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from...
10.
Kuo F, Neville M, Sabaratnam R, Wesolowska-Andersen A, Phillips D, Wittemans L, et al.
Cell Rep
. 2022 Jul;
40(4):111136.
PMID: 35905723
Mechanisms governing regional human adipose tissue (AT) development remain undefined. Here, we show that the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where...