Marcel Hohl
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Explore the profile of Marcel Hohl including associated specialties, affiliations and a list of published articles.
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18
Citations
574
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Recent Articles
1.
Petrini J, Hohl M, Yu Y, Kuryavyi V, Patel D
Res Sq
. 2024 Dec;
PMID: 39711558
The Mre11 complex comprises Mre11, Rad50 and Nbs1 (Xrs2 in ). The core components, Mre11 and Rad50 are highly conserved, with readily identifiable orthologs in all clades of life, whereas...
2.
Wang H, Canasto-Chibuque C, Kim J, Hohl M, Leslie C, Reis-Filho J, et al.
Genes Dev
. 2024 Oct;
38(21-24):979-997.
PMID: 39455282
The MRE11 complex (comprising MRE11, RAD50, and NBS1) is integral to the maintenance of genome stability. We previously showed that a hypomorphic mutant mouse strain ( ) was highly susceptible...
3.
Wang H, Canasto-Chibuque C, Kim J, Hohl M, Leslie C, Reis-Filho J, et al.
bioRxiv
. 2023 Oct;
PMID: 37905095
The Mre11 complex (comprising Mre11, Rad50, Nbs1) is integral to the maintenance of genome stability. We previously showed that a hypomorphic mutant mouse strain ( ) was highly susceptible to...
4.
Ghisays F, Garzia A, Wang H, Canasto-Chibuque C, Hohl M, Savage S, et al.
Nat Commun
. 2021 May;
12(1):3016.
PMID: 34021146
Telomere repeat containing RNAs (TERRAs) are a family of long non-coding RNAs transcribed from the subtelomeric regions of eukaryotic chromosomes. TERRA transcripts can form R-loops at chromosome ends; however the...
5.
Chansel-Da Cruz M, Hohl M, Ceppi I, Kermasson L, Maggiorella L, Modesti M, et al.
Cell Rep
. 2020 Dec;
33(13):108559.
PMID: 33378670
The MRE11-RAD50-NBS1 complex plays a central role in response to DNA double-strand breaks. Here, we identify a patient with bone marrow failure and developmental defects caused by biallelic RAD50 mutations....
6.
Hohl M, Mojumdar A, Hailemariam S, Kuryavyi V, Ghisays F, Sorenson K, et al.
PLoS Genet
. 2020 Mar;
16(3):e1008422.
PMID: 32187176
The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several...
7.
Hailemariam S, De Bona P, Galletto R, Hohl M, Petrini J, Burgers P
J Biol Chem
. 2019 Oct;
294(49):18846-18852.
PMID: 31640985
Tel1 is the ortholog of human ATM kinase and initiates a cell cycle checkpoint in response to dsDNA breaks (DSBs). Tel1 kinase is activated synergistically by naked dsDNA and the...
8.
Mojumdar A, Sorenson K, Hohl M, Toulouze M, Lees-Miller S, Dubrana K, et al.
Cell Rep
. 2019 Aug;
28(6):1564-1573.e3.
PMID: 31390569
Non-homologous end joining (NHEJ) and homologous recombination (HR) are the two major pathways of DNA double-strand break (DSB) repair and both are highly conserved from yeast to mammals. Nej1 has...
9.
Park Y, Hohl M, Padjasek M, Jeong E, Jin K, Krezel A, et al.
Nat Struct Mol Biol
. 2017 Jan;
24(3):248-257.
PMID: 28134932
The Rad50 hook interface is crucial for assembly and various functions of the Mre11 complex. Previous analyses suggested that Rad50 molecules interact within (intracomplex) or between (intercomplex) dimeric complexes. In...
10.
Hohl M, Kochanczyk T, Tous C, Aguilera A, Krezel A, Petrini J
Mol Cell
. 2015 Jan;
57(3):479-91.
PMID: 25601756
Rad50 contains a conserved Zn(2+) coordination domain (the Rad50 hook) that functions as a homodimerization interface. Hook ablation phenocopies Rad50 deficiency in all respects. Here, we focused on rad50 mutations...