Marcel Hohl
Overview
Explore the profile of Marcel Hohl including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
574
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0
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Recent Articles
11.
Al-Ahmadie H, Iyer G, Hohl M, Asthana S, Inagaki A, Schultz N, et al.
Cancer Discov
. 2014 Jun;
4(9):1014-21.
PMID: 24934408
Unlabelled: Metastatic solid tumors are almost invariably fatal. Patients with disseminated small-cell cancers have a particularly unfavorable prognosis, with most succumbing to their disease within two years. Here, we report...
12.
Roset R, Inagaki A, Hohl M, Brenet F, Lafrance-Vanasse J, Lange J, et al.
Genes Dev
. 2014 Feb;
28(5):451-62.
PMID: 24532689
The Mre11 complex (Mre11, Rad50, and Nbs1) is a central component of the DNA damage response (DDR), governing both double-strand break repair and DDR signaling. Rad50 contains a highly conserved...
13.
Tittel-Elmer M, Lengronne A, Davidson M, Bacal J, Francois P, Hohl M, et al.
Mol Cell
. 2012 Aug;
48(1):98-108.
PMID: 22885006
The cohesin complex holds together newly replicated chromatids and is involved in diverse pathways that preserve genome integrity. We show that in budding yeast, cohesin is transiently recruited to active...
14.
Hohl M, Kwon Y, Galvan S, Xue X, Tous C, Aguilera A, et al.
Nat Struct Mol Biol
. 2011 Sep;
18(10):1124-31.
PMID: 21892167
The Mre11 complex (Mre11, Rad50 and Xrs2 in Saccharomyces cerevisiae) influences diverse functions in the DNA damage response. The complex comprises the globular DNA-binding domain and the Rad50 hook domain,...
15.
Hohl M, Dunand-Sauthier I, Staresincic L, Jaquier-Gubler P, Thorel F, Modesti M, et al.
Nucleic Acids Res
. 2007 Apr;
35(9):3053-63.
PMID: 17452369
FEN-1 and XPG are members of the FEN-1 family of structure-specific nucleases, which share a conserved active site. FEN-1 plays a central role in DNA replication, whereas XPG is involved...
16.
Wiltzius J, Hohl M, Fleming J, Petrini J
Nat Struct Mol Biol
. 2005 Apr;
12(5):403-7.
PMID: 15852023
The Mre11 complex (in Saccharomyces cerevisiae: Mre11, Rad50 and Xrs2) influences multiple facets of chromosome break metabolism. A conserved feature of the Mre11 complex is a zinc-coordinating motif in Rad50...
17.
Dunand-Sauthier I, Hohl M, Thorel F, Jaquier-Gubler P, Clarkson S, Scharer O
J Biol Chem
. 2004 Dec;
280(8):7030-7.
PMID: 15590680
XPG has structural and catalytic roles in nucleotide excision repair (NER) and belongs to the FEN-1 family of structure-specific nucleases. XPG contains a stretch of over 600 amino acids termed...
18.
Hohl M, Thorel F, Clarkson S, Scharer O
J Biol Chem
. 2003 Mar;
278(21):19500-8.
PMID: 12644470
XPG belongs to the Fen1 family of structure-specific nucleases and is responsible for the 3' endonucleolytic incision during mammalian nucleotide excision repair. In addition, it has ill-defined roles in the...