Jorge S Reis-Filho
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Explore the profile of Jorge S Reis-Filho including associated specialties, affiliations and a list of published articles.
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533
Citations
29574
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Recent Articles
1.
Jalan M, Brambati A, Shah H, McDermott N, Patel J, Zhu Y, et al.
bioRxiv
. 2025 Mar;
PMID: 40060534
Double-strand breaks (DSBs) are toxic lesions that lead to genome instability. While canonical DSB repair pathways typically operate independently of RNA, emerging evidence suggests that RNA:DNA hybrids and transcripts near...
2.
Boehm K, El Nahhas O, Marra A, Waters M, Jee J, Braunstein L, et al.
Nat Commun
. 2025 Mar;
16(1):2106.
PMID: 40025017
The Oncotype DX® Recurrence Score (RS) is an assay for hormone receptor-positive early breast cancer with extensively validated predictive and prognostic value. However, its cost and lag time have limited...
3.
Pareja F, Bhargava R, Borges V, Brogi E, Canas Marques R, Cardoso F, et al.
NPJ Breast Cancer
. 2025 Jan;
11(1):6.
PMID: 39856067
Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel...
4.
Kudo R, Safonov A, Jones C, Moiso E, Dry J, Shao H, et al.
Cancer Cell
. 2024 Nov;
42(11):1983.
PMID: 39532066
No abstract available.
5.
Jee J, Fong C, Pichotta K, Tran T, Luthra A, Waters M, et al.
Nature
. 2024 Nov;
636(8043):728-736.
PMID: 39506116
The digitization of health records and growing availability of tumour DNA sequencing provide an opportunity to study the determinants of cancer outcomes with unprecedented richness. Patient data are often stored...
6.
Wang H, Canasto-Chibuque C, Kim J, Hohl M, Leslie C, Reis-Filho J, et al.
Genes Dev
. 2024 Oct;
38(21-24):979-997.
PMID: 39455282
The MRE11 complex (comprising MRE11, RAD50, and NBS1) is integral to the maintenance of genome stability. We previously showed that a hypomorphic mutant mouse strain ( ) was highly susceptible...
7.
Kudo R, Safonov A, Jones C, Moiso E, Dry J, Shao H, et al.
Cancer Cell
. 2024 Oct;
42(11):1919-1935.e9.
PMID: 39393354
Inhibition of CDK4/6 kinases has led to improved outcomes in breast cancer. Nevertheless, only a minority of patients experience long-term disease control. Using a large, clinically annotated cohort of patients...
8.
Loeffler C, El Nahhas O, Muti H, Carrero Z, Seibel T, van Treeck M, et al.
BMC Biol
. 2024 Oct;
22(1):225.
PMID: 39379982
Background: Homologous recombination deficiency (HRD) is recognized as a pan-cancer predictive biomarker that potentially indicates who could benefit from treatment with PARP inhibitors (PARPi). Despite its clinical significance, HRD testing...
9.
Safonov A, Marra A, Bandlamudi C, OLeary B, Wubbenhorst B, Ferraro E, et al.
bioRxiv
. 2024 Sep;
PMID: 39253462
The co-occurrence of germline and somatic oncogenic alterations is frequently observed in breast cancer, but their combined biologic and clinical significance has not been evaluated. To assess the role of...
10.
Jalan M, Sharma A, Pei X, Weinhold N, Buechelmaier E, Zhu Y, et al.
Nat Commun
. 2024 Sep;
15(1):7776.
PMID: 39237529
Collisions of the transcription and replication machineries on the same DNA strand can pose a significant threat to genomic stability. These collisions occur in part due to the formation of...