John H J Petrini
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Explore the profile of John H J Petrini including associated specialties, affiliations and a list of published articles.
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73
Citations
3969
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Recent Articles
1.
Wang H, Canasto-Chibuque C, Kim J, Hohl M, Leslie C, Reis-Filho J, et al.
Genes Dev
. 2024 Oct;
38(21-24):979-997.
PMID: 39455282
The MRE11 complex (comprising MRE11, RAD50, and NBS1) is integral to the maintenance of genome stability. We previously showed that a hypomorphic mutant mouse strain ( ) was highly susceptible...
2.
Kim S, Yamada S, Li T, Canasto-Chibuque C, Kim J, Marcet-Ortega M, et al.
bioRxiv
. 2024 Aug;
PMID: 39185212
Nucleolytic resection of DNA ends is critical for homologous recombination, but its mechanism is not fully understood, particularly in mammalian meiosis. Here we examine roles of the conserved MRN complex...
3.
Wardlaw C, Miele M, Li Z, Hendrickson R, Petrini J
STAR Protoc
. 2024 Jan;
5(1):102843.
PMID: 38294909
Ubiquitin-like protein ISG15 plays an important role in an array of cellular functions via its covalent attachment to target proteins (ISGylation). Here, we present a protocol for the identification of...
4.
Wardlaw C, Petrini J
Bioessays
. 2023 May;
45(7):e2300042.
PMID: 37147792
Interferon stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that is highly induced upon activation of interferon signaling and cytoplasmic DNA sensing pathways. As part of the innate immune system...
5.
Wardlaw C, Petrini J
Nat Commun
. 2022 Oct;
13(1):5971.
PMID: 36216822
The pathways involved in suppressing DNA replication stress and the associated DNA damage are critical to maintaining genome integrity. The Mre11 complex is unique among double strand break (DSB) repair...
6.
Fernandez K, Feeney L, Smolkin R, Yen W, Matthews A, Alread W, et al.
Elife
. 2022 Oct;
11.
PMID: 36190107
During the development of humoral immunity, activated B lymphocytes undergo vigorous proliferative, transcriptional, metabolic, and DNA remodeling activities; hence, their genomes are constantly exposed to an onslaught of genotoxic agents...
7.
Ghisays F, Garzia A, Wang H, Canasto-Chibuque C, Hohl M, Savage S, et al.
Nat Commun
. 2021 May;
12(1):3016.
PMID: 34021146
Telomere repeat containing RNAs (TERRAs) are a family of long non-coding RNAs transcribed from the subtelomeric regions of eukaryotic chromosomes. TERRA transcripts can form R-loops at chromosome ends; however the...
8.
Chansel-Da Cruz M, Hohl M, Ceppi I, Kermasson L, Maggiorella L, Modesti M, et al.
Cell Rep
. 2020 Dec;
33(13):108559.
PMID: 33378670
The MRE11-RAD50-NBS1 complex plays a central role in response to DNA double-strand breaks. Here, we identify a patient with bone marrow failure and developmental defects caused by biallelic RAD50 mutations....
9.
Hohl M, Mojumdar A, Hailemariam S, Kuryavyi V, Ghisays F, Sorenson K, et al.
PLoS Genet
. 2020 Mar;
16(3):e1008422.
PMID: 32187176
The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several...
10.
Fagan-Solis K, Simpson D, Kumar R, Martelotto L, Mose L, Rashid N, et al.
Cell Rep
. 2020 Feb;
30(5):1385-1399.e7.
PMID: 32023457
The Mre11-Rad50-Nbs1 complex is a DNA double-strand break sensor that mediates a tumor-suppressive DNA damage response (DDR) in cells undergoing oncogenic stress, yet the mechanisms underlying this effect are poorly...