M C Glennon
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Explore the profile of M C Glennon including associated specialties, affiliations and a list of published articles.
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16
Citations
409
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Recent Articles
1.
McGinn C, Pestalozzi B, Drake J, Glennon M, Kunugi K, Otterson G, et al.
Cancer J
. 2000 Oct;
6(4):234-42.
PMID: 11038143
Purpose: Resistance to 5-fluorouracil (5-FU) has been associated with thymidylate synthase (TS) gene amplification and increased TS protein levels. Increased TS protein expression has also been found to be a...
2.
Kinsella T, Glennon M, Kunugi K, Lindstrom M
Clin Cancer Res
. 1996 Jun;
2(6):981-9.
PMID: 9816259
This in vivo study examines the ability of 5'-amino-5'-deoxythymidine (5'-AdThd) to modulate 5-iododeoxyuridine (IdUrd) cellular metabolism in two human colon cancer xenografts (HT 29 and HCT-116), two actively proliferating normal...
3.
Pestalozzi B, McGinn C, Kinsella T, Drake J, Glennon M, Allegra C, et al.
Br J Cancer
. 1995 Jun;
71(6):1151-7.
PMID: 7779704
We have analysed cell cycle variations in thymidylate synthase (TS) protein in asynchronously growing NCl H630 and HT 29 colon cancer and MCF-7 breast cancer cell lines. Western immunoblot analysis...
4.
Glennon M, Shears S
Biochem J
. 1993 Jul;
293 ( Pt 2):583-90.
PMID: 8343137
We have used a non-transformed cell model, the primary cultured hepatocyte, to explore the turnover of inositol hexakisphosphate, multiple isomers of inositol pentakisphosphate and two novel diphosphoinositol polyphosphates. All of...
5.
Glennon M, Bird G, Takemura H, Thastrup O, Leslie B, Putney Jr J
J Biol Chem
. 1992 Dec;
267(35):25568-75.
PMID: 1460052
The activation of phospholipase C by hormones and neurotransmitters activates a complex combination of Ca2+ release and accumulation by intracellular organelles. Previously, we demonstrated that, in some cell types, the...
6.
Glennon M, Bird G, Kwan C, Putney Jr J
J Biol Chem
. 1992 May;
267(12):8230-3.
PMID: 1533221
When hepatocytes were loaded with fura-2 by incubation with the acetoxymethyl ester (fura-2/AM), addition of Mn2+ resulted in a rapid quench of a fraction of cellular fura-2 fluorescence. Addition of...
7.
Prentki M, Vischer S, Glennon M, Regazzi R, Deeney J, Corkey B
J Biol Chem
. 1992 Mar;
267(9):5802-10.
PMID: 1556096
Several approaches were used to test the hypothesis proposing a role for acyl-CoA esters in nutrient-induced insulin release (Prentki, M., and Matschinsky, F. M. (1987) Physiol. Rev. 67, 1185-1248; Corkey,...
8.
Nogimori K, Hughes P, Glennon M, Hodgson M, Putney Jr J, Shears S
J Biol Chem
. 1991 Sep;
266(25):16499-506.
PMID: 1653239
Hepatic inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity was detected in a 100,000 x g soluble fraction and a detergent-solubilized particulate fraction. Activity in both fractions increased up to 40-fold after anion-exchange chromatography...
9.
Corkey B, Glennon M, Chen K, Deeney J, Matschinsky F, Prentki M
J Biol Chem
. 1989 Dec;
264(36):21608-12.
PMID: 2689441
To gain insight into the relationship between acyl coenzyme A (CoA) esters and glucose-induced insulin release, acyl-CoA profiles were determined in clonal pancreatic beta-cells (HIT). A high sensitivity high performance...
10.
Geschwind J, Hiriart M, Glennon M, Najafi H, Corkey B, Matschinsky F, et al.
Biochim Biophys Acta
. 1989 Jun;
1012(1):107-15.
PMID: 2543452
The action of exogenous ATP on cytoplasmic free Ca2+ ([Ca2+]i) was studied in insulin secreting cells using fura-2. Stimulation of clonal pancreatic beta-cells (HIT) with ATP (range 2-20 microM) evoked...