P G Johnston
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Explore the profile of P G Johnston including associated specialties, affiliations and a list of published articles.
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164
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3260
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Recent Articles
1.
Allen W, Dunne P, McDade S, Scanlon E, Loughrey M, Coleman H, et al.
JCO Precis Oncol
. 2018 Aug;
2018.
PMID: 30088816
Purpose: Transcriptomic profiling of colorectal cancer (CRC) has led to identification of four consensus molecular subtypes (CMS1-4), which have prognostic value in stage II/III disease. More recently, the Colorectal Cancer...
2.
Schmid D, Jarvis G, Fay F, Small D, Greene M, Majkut J, et al.
Cell Death Dis
. 2014 Oct;
5:e1454.
PMID: 25299779
The simultaneous delivery of multiple cancer drugs in combination therapies to achieve optimal therapeutic effects in patients can be challenging. This study investigated whether co-encapsulation of the BH3-mimetic ABT-737 and...
3.
Majkut J, Sgobba M, Holohan C, Crawford N, Logan A, Kerr E, et al.
Nat Commun
. 2014 Mar;
5:3350.
PMID: 24577104
Death receptor activation triggers recruitment of FADD, which via its death effector domain (DED) engages the DEDs of procaspase 8 and its inhibitor FLIP to form death-inducing signalling complexes (DISCs)....
4.
Turkington R, Longley D, Allen W, Stevenson L, McLaughlin K, Dunne P, et al.
Cell Death Dis
. 2014 Feb;
5:e1046.
PMID: 24503538
The discovery of underlying mechanisms of drug resistance, and the development of novel agents to target these pathways, is a priority for patients with advanced colorectal cancer (CRC). We previously...
5.
Riley J, Hutchinson R, McArt D, Crawford N, Holohan C, Paul I, et al.
Cell Death Dis
. 2013 Dec;
4:e951.
PMID: 24309938
Non-small cell lung carcinoma remains by far the leading cause of cancer-related deaths worldwide. Overexpression of FLIP, which blocks the extrinsic apoptotic pathway by inhibiting caspase-8 activation, has been identified...
6.
Crawford N, Stasik I, Holohan C, Majkut J, McGrath M, Johnston P, et al.
Cell Death Dis
. 2013 Jul;
4:e733.
PMID: 23868066
Malignant pleural mesothelioma (MPM) is a highly pro-inflammatory malignancy that is rapidly fatal and increasing in incidence. Cytokine signaling within the pro-inflammatory tumor microenvironment makes a critical contribution to the...
7.
Hector S, Conlon S, Schmid J, Dicker P, Cummins R, Concannon C, et al.
Br J Cancer
. 2012 Apr;
106(9):1499-1505.
PMID: 22481083
Background: Critical to successful execution of mitochondrial-mediated apoptosis is apoptosome formation and subsequent activation of caspases. Defects in this pathway have an important role in colorectal carcinogenesis and chemoresistance; therefore,...
8.
Kerr E, Holohan C, McLaughlin K, Majkut J, Dolan S, Redmond K, et al.
Cell Death Differ
. 2012 Feb;
19(8):1317-27.
PMID: 22322857
FLIP is a potential anti-cancer therapeutic target that inhibits apoptosis by blocking caspase 8 activation by death receptors. We report a novel interaction between FLIP and the DNA repair protein...
9.
Gormley J, Hegarty S, OGrady A, Stevenson M, Burden R, Barrett H, et al.
Br J Cancer
. 2011 Oct;
105(10):1487-94.
PMID: 21989182
Background: The aim of this pilot retrospective study was to investigate the immunohistochemical expression of Cathepsin S (CatS) in three cohorts of colorectal cancer (CRC) patients (n=560). Methods: Prevalence and...
10.
Oladipo O, Conlon S, OGrady A, Purcell C, Wilson C, Maxwell P, et al.
Br J Cancer
. 2011 Feb;
104(3):480-7.
PMID: 21285972
Background: The CXC-chemokine expression is linked with colorectal cancer (CRC) progression but their significance in resected CRC is unclear. We explored the prognostic impact of such expression in stage II...