Lukasz Mioduszewski
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Explore the profile of Lukasz Mioduszewski including associated specialties, affiliations and a list of published articles.
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9
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52
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Recent Articles
1.
Mioduszewski L
Eur Biophys J
. 2023 Jun;
52(6-7):583-591.
PMID: 37378869
Large coarse-grained simulations are often conducted with an implicit solvent, which makes it hard to assess the water content of the sample and the effective concentration of the system. Here...
2.
Cieplak M, Mioduszewski L, Chwastyk M
Methods Mol Biol
. 2022 Feb;
2340:105-120.
PMID: 35167072
We review the contact-based description of aggregation of intrinsically disordered proteins in coarse-grained and all-atom models. We consider polyglutamines and polyalanines at various concentrations of the peptides. We also study...
3.
Narczyk M, Mioduszewski L, Oksiejuk A, Winiewska-Szajewska M, Wielgus-Kutrowska B, Gojdz A, et al.
Sci Rep
. 2021 May;
11(1):11144.
PMID: 34045551
E. coli purine nucleoside phosphorylase is a homohexamer, which structure, in the apo form, can be described as a trimer of dimers. Earlier studies suggested that ligand binding and kinetic...
4.
Mioduszewski L, Cieplak M
PLoS Comput Biol
. 2021 Mar;
17(3):e1008840.
PMID: 33760823
Wheat (Triticum spp.) gluten consists mainly of intrinsincally disordered storage proteins (glutenins and gliadins) that can form megadalton-sized networks. These networks are responsible for the unique viscoelastic properties of wheat...
5.
Cieplak M, Chwastyk M, Mioduszewski L, de Aquino B
Prog Mol Biol Transl Sci
. 2020 Aug;
174:79-103.
PMID: 32828471
We provide a brief overview of the topological features found in structured proteins and of the dynamical processes that involve knots. We then discuss the knotted states that arise in...
6.
Mioduszewski L, Cieplak M
Phys Chem Chem Phys
. 2020 Jul;
22(27):15592-15599.
PMID: 32613961
In order to gain insight into the formation of proteinaceous liquid droplets, we study systems of many disordered homopeptide chains within our coarse-grained molecular dynamics model with conformation-dependent terms. We...
7.
Mioduszewski L, Rozycki B, Cieplak M
J Chem Theory Comput
. 2020 May;
16(7):4726-4733.
PMID: 32436706
We present a new coarse-grained C-based protein model with a nonradial multibody pseudo-improper-dihedral potential that is transferable, time-independent, and suitable for molecular dynamics. It captures the nature of backbone and...
8.
Mioduszewski L, Cieplak M
Phys Chem Chem Phys
. 2018 Jul;
20(28):19057-19070.
PMID: 29972174
We construct a one-bead-per-residue coarse-grained dynamical model to describe intrinsically disordered proteins at significantly longer timescales than in the all-atom models. In this model, inter-residue contacts form and disappear during...
9.
Rozycki B, Mioduszewski L, Cieplak M
Proteins
. 2014 Aug;
82(11):3144-53.
PMID: 25142868
Using coarse-grained molecular dynamics simulations, we analyze mechanically induced dissociation and unfolding of the protein complex CD48-2B4. This heterodimer is an indispensable component of the immunological system: 2B4 is a...