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» Authors » Agnieszka Bzowska

Agnieszka Bzowska

Explore the profile of Agnieszka Bzowska including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 68
Citations 323
Followers 0
Related Specialties
Biochemistry
Molecular Biology
Chemistry
Top 10 Co-Authors
Beata Wielgus-Kutrowska
Marta Narczyk
Marija Luic
Tsutomu Yokomatsu
Sadao Hikishima
Jacek Wierzchowski
Mariko Hashimoto
Ivana Lescic Asler
Katarzyna Breer
Lucyna Magnowska
Published In
Nucleosides Nucleotides Nucleic Acids
Int J Mol Sci
Nucleic Acids Symp Ser (Oxf)
Molecules
Sci Rep
Affiliations
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Recent Articles
1.
Interaction of Tri-Cyclic Nucleobase Analogs with Enzymes of Purine Metabolism: Xanthine Oxidase and Purine Nucleoside Phosphorylase
Stachelska-Wierzchowska A, Narczyk M, Wierzchowski J, Bzowska A, Wielgus-Kutrowska B
Int J Mol Sci . 2024 Oct; 25(19). PMID: 39408755
Fluorescent markers play important roles in spectroscopic and microscopic research techniques and are broadly used in basic and applied sciences. We have obtained markers with fluorescent properties, two etheno derivatives...
2.
Vitamin B6 inhibits activity of adenylosuccinate synthetase and growth of reference and clinical, antibiotic-resistant strains
Wojtys M, Maksymiuk W, Narczyk M, Bubic A, Asler I, Krzyzek P, et al.
J Enzyme Inhib Med Chem . 2024 Aug; 39(1):2372734. PMID: 39149761
The current therapies against gastric pathogen are ineffective in over 20% of patients. Enzymes belonging to the purine salvage pathway are considered as novel drug targets in this pathogen. Therefore,...
3.
Location Is Everything: Influence of His-Tag Fusion Site on Properties of Adenylosuccinate Synthetase from
Miskovic M, Wojtys M, Winiewska-Szajewska M, Wielgus-Kutrowska B, Matkovic M, Domazet Jurasin D, et al.
Int J Mol Sci . 2024 Jul; 25(14). PMID: 39062851
The requirement for fast and dependable protein purification methods is constant, either for functional studies of natural proteins or for the production of biotechnological protein products. The original procedure has...
4.
Trimeric Architecture Ensures the Stability and Biological Activity of the Calf Purine Nucleoside Phosphorylase: In Silico and In Vitro Studies of Monomeric and Trimeric Forms of the Enzyme
Dyzma A, Wielgus-Kutrowska B, Girstun A, Jelic Matosevic Z, Staron K, Bertosa B, et al.
Int J Mol Sci . 2023 Feb; 24(3). PMID: 36768477
Mammalian purine nucleoside phosphorylase (PNP) is biologically active as a homotrimer, in which each monomer catalyzes a reaction independently of the others. To answer the question of why the native...
5.
The pursuit of new alternative ways to eradicate Helicobacter pylori continues: Detailed characterization of interactions in the adenylosuccinate synthetase active site
Bubic A, Narczyk M, Petek A, Wojtys M, Maksymiuk W, Wielgus-Kutrowska B, et al.
Int J Biol Macromol . 2022 Dec; 226:37-50. PMID: 36470440
Purine nucleotide synthesis is realised only through the salvage pathway in pathogenic bacterium Helicobacter pylori. Therefore, the enzymes of this pathway, among them also the adenylosuccinate synthetase (AdSS), present potential...
6.
Interactions of 2,6-substituted purines with purine nucleoside phosphorylase from in solution and in the crystal, and the effects of these compounds on cell cultures of this bacterium
Narczyk M, Wojtys M, Asler I, Zinic B, Luic M, Jagusztyn-Krynicka E, et al.
J Enzyme Inhib Med Chem . 2022 Apr; 37(1):1083-1097. PMID: 35437103
represents a global health threat with around 50% of the world population infected. Due to the increasing number of antibiotic-resistant strains, new strategies for eradication of are needed. In this...
7.
A comprehensive method for determining cellular uptake of purine nucleoside phosphorylase and adenylosuccinate synthetase inhibitors by H. pylori
Wojtys M, Jazwiec R, Kazazic S, Asler I, Knezevic P, Aleksic Sabo V, et al.
Appl Microbiol Biotechnol . 2021 Sep; 105(20):7949-7967. PMID: 34562116
Due to the growing number of Helicobacter pylori strains resistant to currently available antibiotics, there is an urgent need to design new drugs utilizing different molecular mechanisms than those that...
8.
Chromophore of an Enhanced Green Fluorescent Protein Can Play a Photoprotective Role Due to Photobleaching
Krasowska J, Pierzchala K, Bzowska A, Forro L, Sienkiewicz A, Wielgus-Kutrowska B
Int J Mol Sci . 2021 Aug; 22(16). PMID: 34445269
Under stress conditions, elevated levels of cellular reactive oxygen species (ROS) may impair crucial cellular structures. To counteract the resulting oxidative damage, living cells are equipped with several defense mechanisms,...
9.
Single tryptophan Y160W mutant of homooligomeric E. coli purine nucleoside phosphorylase implies that dimers forming the hexamer are functionally not equivalent
Narczyk M, Mioduszewski L, Oksiejuk A, Winiewska-Szajewska M, Wielgus-Kutrowska B, Gojdz A, et al.
Sci Rep . 2021 May; 11(1):11144. PMID: 34045551
E. coli purine nucleoside phosphorylase is a homohexamer, which structure, in the apo form, can be described as a trimer of dimers. Earlier studies suggested that ligand binding and kinetic...
10.
Molecular Mechanism of Thymidylate Synthase Inhibition by N-Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies
Maj P, Jarmula A, Wilk P, Prokopowicz M, Rypniewski W, Zielinski Z, et al.
Int J Mol Sci . 2021 May; 22(9). PMID: 33946210
Novel evidence is presented allowing further clarification of the mechanism of the slow-binding thymidylate synthase (TS) inhibition by N-hydroxy-dCMP (N-OH-dCMP). Spectrophotometric monitoring documented time- and temperature-, and N-OH-dCMP-dependent TS-catalyzed dihydrofolate...