Lukas Hroch
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Explore the profile of Lukas Hroch including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
111
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Recent Articles
1.
Benek O, Vaskova M, Miskerikova M, Schmidt M, Andrys R, Rotterova A, et al.
Eur J Med Chem
. 2023 Jun;
258:115593.
PMID: 37390508
17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) is a multifunctional mitochondrial enzyme and putative drug target for the treatment of various pathologies including Alzheimer's disease or some types of hormone-dependent cancer. In...
2.
Fisar Z, Musilek K, Benek O, Hroch L, Vinklarova L, Schmidt M, et al.
Toxicol Lett
. 2020 Dec;
339:12-19.
PMID: 33359020
Mitochondrial enzymes are targets of newly synthesized drugs being tested for the treatment of neurodegenerative disorders, such as Alzheimer's disease (AD). The enzyme 17β-hydroxysteroid dehydrogenase type 10 (HSD10) is a...
3.
Schmidt M, Benek O, Vinklarova L, Hrabinova M, Zemanova L, Chribek M, et al.
Int J Mol Sci
. 2020 Mar;
21(6).
PMID: 32192199
Human 17β-hydroxysteroid dehydrogenase type 10 is a multifunctional protein involved in many enzymatic and structural processes within mitochondria. This enzyme was suggested to be involved in several neurological diseases, e.g.,...
4.
Aitken L, Benek O, McKelvie B, Hughes R, Hroch L, Schmidt M, et al.
Molecules
. 2019 Aug;
24(15).
PMID: 31362457
It has long been established that mitochondrial dysfunction in Alzheimer's disease (AD) patients can trigger pathological changes in cell metabolism by altering metabolic enzymes such as the mitochondrial 17β-hydroxysteroid dehydrogenase...
5.
Benek O, Hroch L, Aitken L, Gunn-Moore F, Vinklarova L, Kuca K, et al.
J Enzyme Inhib Med Chem
. 2018 Mar;
33(1):665-670.
PMID: 29536773
Several neurodegenerative disorders including Alzheimer's disease (AD) have been connected with deregulation of casein kinase 1 (CK1) activity. Inhibition of CK1 therefore presents a potential therapeutic strategy against such pathologies....
6.
Honegr J, Malinak D, Dolezal R, Soukup O, Benkova M, Hroch L, et al.
Eur J Med Chem
. 2018 Feb;
146:38-46.
PMID: 29407964
The purpose of this study was to identify new small molecules that possess activity on human toll-like receptor 4 associated with the myeloid differentiation protein 2 (hTLR4/MD2). Following current rational...
7.
Loveridge E, Hroch L, Hughes R, Williams T, Davies R, Angelastro A, et al.
Biochemistry
. 2017 Mar;
56(13):1879-1886.
PMID: 28319664
Mammalian dihydrofolate reductases (DHFRs) catalyze the reduction of folate more efficiently than the equivalent bacterial enzymes do, despite typically having similar efficiencies for the reduction of their natural substrate, dihydrofolate....
8.
Hroch L, Guest P, Benek O, Soukup O, Janockova J, Dolezal R, et al.
Bioorg Med Chem
. 2017 Jan;
25(3):1143-1152.
PMID: 28082069
Alzheimer's disease (AD) is a neurodegenerative disorder associated with an excessive accumulation of amyloid-beta peptide (Aβ). Based on the multifactorial nature of AD, preparation of multi-target-directed ligands presents a viable...
9.
Benek O, Hroch L, Aitken L, Dolezal R, Guest P, Benkova M, et al.
Med Chem
. 2017 Jan;
PMID: 28067167
Background: The mitochondrial enzyme amyloid beta-binding alcohol dehydrogenase (ABAD) also known as 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) has been connected with the pathogenesis of Alzheimer's disease (AD). ABAD/ 17β-HSD10 is...
10.
Hroch L, Benek O, Guest P, Aitken L, Soukup O, Janockova J, et al.
Bioorg Med Chem Lett
. 2016 Jun;
26(15):3675-8.
PMID: 27287370
Amyloid-beta peptide (Aβ) has been recognized to interact with numerous proteins, which may lead to pathological changes in cell metabolism of Alzheimer's disease (AD) patients. One such known metabolic enzyme...