Frank Gunn-Moore
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Explore the profile of Frank Gunn-Moore including associated specialties, affiliations and a list of published articles.
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44
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1378
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Recent Articles
1.
Benek O, Vaskova M, Miskerikova M, Schmidt M, Andrys R, Rotterova A, et al.
Eur J Med Chem
. 2023 Jun;
258:115593.
PMID: 37390508
17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) is a multifunctional mitochondrial enzyme and putative drug target for the treatment of various pathologies including Alzheimer's disease or some types of hormone-dependent cancer. In...
2.
Vacher M, Durrant C, Rose J, Hall A, Spires-Jones T, Gunn-Moore F, et al.
Eur J Neurosci
. 2022 Dec;
57(7):1161-1179.
PMID: 36514861
Alzheimer's disease (AD) is the most common neurodegenerative disease and the primary cause of disability and dependency among elderly humans worldwide. AD is thought to be a disease unique to...
3.
Chen D, Yu W, Aitken L, Gunn-Moore F
Cells
. 2022 Oct;
11(19).
PMID: 36231104
Willin/ has been reported as a potential Alzheimer's disease (AD) risk gene in a series of genome-wide association and neuroimaging studies; however, the mechanisms underlying its potential role in AD...
4.
Metodieva V, Smith T, Gunn-Moore F
eNeuro
. 2022 Sep;
9(5).
PMID: 36096650
Severe brain metabolic dysfunction and amyloid-β accumulation are key hallmarks of Alzheimer's disease (AD). While astrocytes contribute to both pathologic mechanisms, the role of their mitochondria, which is essential for...
5.
Chen D, Yu W, Aitken L, Gunn-Moore F
Cells
. 2021 Nov;
10(11).
PMID: 34831245
The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton dynamics and mechanical phenotype...
6.
Broadhead M, Bonthron C, Arcinas L, Bez S, Zhu F, Goff F, et al.
Sci Rep
. 2021 Nov;
11(1):23160.
PMID: 34819586
No abstract available.
7.
Broadhead M, Bonthron C, Arcinas L, Bez S, Zhu F, Goff F, et al.
Sci Rep
. 2020 May;
10(1):8189.
PMID: 32424125
Functionally distinct synapses exhibit diverse and complex organisation at molecular and nanoscale levels. Synaptic diversity may be dependent on developmental stage, anatomical locus and the neural circuit within which synapses...
8.
Vinklarova L, Schmidt M, Benek O, Kuca K, Gunn-Moore F, Musilek K
J Neurochem
. 2020 Apr;
155(3):231-249.
PMID: 32306391
17β-hydroxysteroid dehydrogenase (17β-HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has important...
9.
Schmidt M, Benek O, Vinklarova L, Hrabinova M, Zemanova L, Chribek M, et al.
Int J Mol Sci
. 2020 Mar;
21(6).
PMID: 32192199
Human 17β-hydroxysteroid dehydrogenase type 10 is a multifunctional protein involved in many enzymatic and structural processes within mitochondria. This enzyme was suggested to be involved in several neurological diseases, e.g.,...
10.
Yu Q, Wang Y, Du F, Yan S, Hu G, Origlia N, et al.
Nat Commun
. 2018 Aug;
9(1):2968.
PMID: 30061577
Endophilin A1 (EP) is a protein enriched in synaptic terminals that has been linked to Alzheimer's disease (AD). Previous in vitro studies have shown that EP can bind to a...