Luiz Carlos Dias
Overview
Explore the profile of Luiz Carlos Dias including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
92
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0
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Recent Articles
1.
Espinoza-Chavez R, de Oliveira Rezende Junior C, De Souza M, Consolin Chelucci R, Michelan-Duarte S, Krogh R, et al.
ChemMedChem
. 2024 Jun;
19(20):e202400293.
PMID: 38924252
This study introduces further insights from the hit-to-lead optimization process involving a series of benzimidazole derivatives acting as inhibitors of the cruzain enzyme, which targets Trypanosoma cruzi, the causative parasite...
2.
Espinoza-Chavez R, de Oliveira Rezende Junior C, De Souza M, Pauli I, Valli M, Gomes Ferreira L, et al.
Future Med Chem
. 2024 Jan;
16(3):253-269.
PMID: 38193294
Chagas disease is caused by the parasite , and the lack of effective and safe treatments makes identifying new classes of compounds with anti- activity of paramount importance. Hit-to-lead exploration...
3.
de Oliveira Rezende Junior C, Martinez P, Ferreira R, Koovits P, Miranda Soares B, Ferreira L, et al.
Eur J Med Chem
. 2022 Dec;
246:114925.
PMID: 36459758
Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi. Because current treatments present several limitations, including long duration, variable efficacy and serious side effects, there is an urgent...
4.
Pinto Braga S, Correa Santos V, Vieira R, Barbosa da Silva E, Monti L, Krake S, et al.
Eur J Med Chem
. 2022 Nov;
244:114876.
PMID: 36343429
Chagas disease is a major public health problem caused by Trypanosoma cruzi, with an estimated 6-7 million people infected and 70 million at risk of infection. T. brucei gambiense and...
5.
Medeiros A, Ferreira L, de Souza M, de Oliveira Rezende Junior C, Espinoza-Chavez R, Carlos Dias L, et al.
Biomolecules
. 2021 Apr;
11(4).
PMID: 33920961
Natural products based on imidazole scaffolds have inspired the discovery of a wide variety of bioactive compounds. Herein, a series of imidazoles that act as competitive and potent cruzain inhibitors...
6.
Ferreira R, de Oliveira Rezende Junior C, Martinez P, Koovits P, Miranda Soares B, Ferreira L, et al.
PLoS Negl Trop Dis
. 2021 Feb;
15(2):e0009196.
PMID: 33617566
Leishmaniasis is a major infectious disease with hundreds of thousands of new cases and over 20,000 deaths each year. The current drugs to treat this life-threatening infection have several drawbacks...
7.
de Souza M, de Oliveira Rezende Junior C, Ferreira R, Espinoza Chavez R, Ferreira L, Slafer B, et al.
J Chem Inf Model
. 2019 Nov;
60(2):1028-1041.
PMID: 31765144
A virtual screening conducted with nearly 4 000 000 compounds from lead-like and fragment-like subsets enabled the identification of a small-molecule inhibitor () of the cruzain enzyme, a validated drug...
8.
Pereira de SantAna D, de Oliveira Rezende Junior C, Campagne J, Carlos Dias L, Marcia de Figueiredo R
J Org Chem
. 2019 Sep;
84(19):12344-12357.
PMID: 31480837
The studies culminating in the synthesis of two large subunits of tautomycetin are described. The first one, fragment C1-C12 that has an -1,3-dimethyl system and a terminal diene unit, was...
9.
Fernandes A, Leonarczyk I, Ferreira M, Carlos Dias L
Org Biomol Chem
. 2019 Mar;
17(12):3167-3180.
PMID: 30838365
In this work, using DFT calculations, we investigated the 1,4 and 1,5 asymmetric induction in boron enolate aldol reactions of α-alkoxy and α,β-bisalkoxy methyl ketones. We evaluated the steric influence...
10.
Krake S, Martinez P, McLaren J, Ryan E, Chen G, White K, et al.
Eur J Med Chem
. 2016 Dec;
126:929-936.
PMID: 28002775
Phenotypic HTS campaigns with a blood stage malaria assay have been used to discover novel chemotypes for malaria treatment with potential alternative mechanisms of action compared to existing agents. N-(5-(3-Chloro-4-fluorophenyl)furan-2-yl)-N,N-dimethylpropane-1,3-diamine,...